APC

APC regulator of WNT signaling pathway

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
20976827 Kidney Mouse NO

GO terms:

Biological Process:
mitotic cytokinesis [GO:0000281],
cell fate specification [GO:0001708],
cellular response to DNA damage stimulus [GO:0006974],
negative regulation of microtubule depolymerization [GO:0007026],
cell cycle arrest [GO:0007050],
mitotic spindle assembly checkpoint [GO:0007094],
cell adhesion [GO:0007155],
pattern specification process [GO:0007389],
negative regulation of cell proliferation [GO:0008285],
insulin receptor signaling pathway [GO:0008286],
positive regulation of cell death [GO:0010942],
Wnt signaling pathway [GO:0016055],
cell migration [GO:0016477],
protein deubiquitination [GO:0016579],
positive regulation of cell migration [GO:0030335],
positive regulation of pseudopodium assembly [GO:0031274],
regulation of microtubule-based process [GO:0032886],
positive regulation of apoptotic process [GO:0043065],
regulation of cell differentiation [GO:0045595],
positive regulation of protein catabolic process [GO:0045732],
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736],
protein homooligomerization [GO:0051260],
regulation of attachment of spindle microtubules to kinetochore [GO:0051988],
macromolecular complex assembly [GO:0065003],
bicellular tight junction assembly [GO:0070830],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of protein localization to centrosome [GO:1904781],
beta-catenin destruction complex assembly [GO:1904885],
beta-catenin destruction complex disassembly [GO:1904886],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
kidney development [GO:0001822],
hair follicle development [GO:0001942],
metaphase/anaphase transition of mitotic cell cycle [GO:0007091],
establishment or maintenance of cell polarity [GO:0007163],
axonogenesis [GO:0007409],
axis specification [GO:0009798],
anterior/posterior pattern specification [GO:0009952],
dorsal/ventral pattern formation [GO:0009953],
proximal/distal pattern formation [GO:0009954],
stem cell population maintenance [GO:0019827],
negative regulation of Wnt signaling pathway [GO:0030178],
regulation of cell migration [GO:0030334],
regulation of epithelial cell differentiation [GO:0030856],
positive regulation of epithelial cell differentiation [GO:0030858],
positive regulation of microtubule polymerization [GO:0031116],
cytoplasmic microtubule organization [GO:0031122],
neuron projection development [GO:0031175],
T cell differentiation in thymus [GO:0033077],
somatic stem cell population maintenance [GO:0035019],
negative regulation of odontogenesis [GO:0042483],
negative regulation of apoptotic process [GO:0043066],
negative regulation of MAPK cascade [GO:0043409],
skin development [GO:0043588],
negative regulation of molecular function [GO:0044092],
canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336],
canonical Wnt signaling pathway involved in positive regulation of apoptotic process [GO:0044337],
positive regulation of cell differentiation [GO:0045597],
regulation of osteoblast differentiation [GO:0045667],
regulation of osteoclast differentiation [GO:0045670],
positive regulation of cell adhesion [GO:0045785],
muscle cell cellular homeostasis [GO:0046716],
thymus development [GO:0048538],
negative regulation of epithelial cell proliferation [GO:0050680],
regulation of nitrogen compound metabolic process [GO:0051171],
chromosome organization [GO:0051276],
regulation of cell cycle [GO:0051726],
positive regulation of cell division [GO:0051781],
retina development in camera-type eye [GO:0060041],
negative regulation of cardiac muscle cell proliferation [GO:0060044],
canonical Wnt signaling pathway [GO:0060070],
negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770],
regulation of glutamate metabolic process [GO:2000211],

Molecular Function:
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
microtubule binding [GO:0008017],
protein kinase regulator activity [GO:0019887],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
gamma-catenin binding [GO:0045295],
cadherin binding [GO:0045296],
microtubule plus-end binding [GO:0051010],
dynein complex binding [GO:0070840],
protease binding [GO:0002020],
macromolecular complex binding [GO:0044877],

Cellular Component:
kinetochore [GO:0000776],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
centrosome [GO:0005813],
cytosol [GO:0005829],
microtubule [GO:0005874],
cytoplasmic microtubule [GO:0005881],
plasma membrane [GO:0005886],
cell-cell adherens junction [GO:0005913],
bicellular tight junction [GO:0005923],
lateral plasma membrane [GO:0016328],
catenin complex [GO:0016342],
lamellipodium [GO:0030027],
beta-catenin destruction complex [GO:0030877],
ruffle membrane [GO:0032587],
perinuclear region of cytoplasm [GO:0048471],
Wnt signalosome [GO:1990909],
cytoskeleton [GO:0005856],
cell cortex [GO:0005938],
membrane [GO:0016020],
cell junction [GO:0030054],
axon [GO:0030424],
dendrite [GO:0030425],
growth cone [GO:0030426],
cell projection membrane [GO:0031253],
nuclear membrane [GO:0031965],
macromolecular complex [GO:0032991],
Scrib-APC-beta-catenin complex [GO:0034750],
microtubule plus-end [GO:0035371],
cell projection [GO:0042995],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
axonal growth cone [GO:0044295],
neuron projection terminus [GO:0044306],
synapse [GO:0045202],
cell body fiber [GO:0070852],