IL12A

interleukin 12A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
positive regulation of T cell mediated cytotoxicity [GO:0001916],
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860],
immune response [GO:0006955],
cell cycle arrest [GO:0007050],
response to virus [GO:0009615],
response to UV-B [GO:0010224],
regulation of receptor activity [GO:0010469],
cell migration [GO:0016477],
cytokine-mediated signaling pathway [GO:0019221],
response to lipopolysaccharide [GO:0032496],
negative regulation of interleukin-17 production [GO:0032700],
positive regulation of interferon-gamma production [GO:0032729],
positive regulation of natural killer cell activation [GO:0032816],
positive regulation of mononuclear cell proliferation [GO:0032946],
positive regulation of smooth muscle cell apoptotic process [GO:0034393],
interleukin-12-mediated signaling pathway [GO:0035722],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
positive regulation of cell adhesion [GO:0045785],
positive regulation of natural killer cell mediated cytotoxicity [GO:0045954],
negative regulation of smooth muscle cell proliferation [GO:0048662],
positive regulation of lymphocyte proliferation [GO:0050671],
defense response to Gram-positive bacterium [GO:0050830],
positive regulation of NK T cell activation [GO:0051135],
interleukin-35-mediated signaling pathway [GO:0070757],
extrinsic apoptotic signaling pathway [GO:0097191],
cellular response to virus [GO:0098586],
positive regulation of dendritic cell chemotaxis [GO:2000510],
cell proliferation [GO:0008283],
interferon-gamma production [GO:0032609],
T-helper 1 cell activation [GO:0035711],
T-helper 1 cell cytokine production [GO:0035744],
positive regulation of T cell proliferation [GO:0042102],
defense response to protozoan [GO:0042832],
positive regulation of T cell differentiation [GO:0045582],
cellular response to lipopolysaccharide [GO:0071222],

Molecular Function:
cytokine activity [GO:0005125],
interleukin-12 receptor binding [GO:0005143],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
interleukin-12 beta subunit binding [GO:0042163],
interleukin-27 binding [GO:0045513],
protein heterodimerization activity [GO:0046982],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
late endosome lumen [GO:0031906],
interleukin-12 complex [GO:0043514],
cytoplasm [GO:0005737],
cell surface [GO:0009986],