IGFBP5

insulin like growth factor binding protein 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15489060 Fibroblasts Human NO
17804819 HUVEC, MEF Human, mouse NO
21233283 MCF7, 293T Human NO
22374671 TIG-3 Human NO
24960204 Primary fibroblasts derived from ear Mouse NO
26762731 Primary myoblasts derived from skeletal muscle Human, mouse NO
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29187894 NCI-H23 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27752126 HUVEC Human NO

GO terms:

Biological Process:
regulation of cell growth [GO:0001558],
osteoblast differentiation [GO:0001649],
glucose metabolic process [GO:0006006],
signal transduction [GO:0007165],
female pregnancy [GO:0007565],
aging [GO:0007568],
regulation of glucose metabolic process [GO:0010906],
negative regulation of smooth muscle cell migration [GO:0014912],
negative regulation of translation [GO:0017148],
negative regulation of cell migration [GO:0030336],
hair follicle morphogenesis [GO:0031069],
intracellular signal transduction [GO:0035556],
glucose homeostasis [GO:0042593],
regulation of insulin-like growth factor receptor signaling pathway [GO:0043567],
positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568],
negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
type B pancreatic cell proliferation [GO:0044342],
negative regulation of osteoblast differentiation [GO:0045668],
negative regulation of growth [GO:0045926],
lung alveolus development [GO:0048286],
negative regulation of smooth muscle cell proliferation [GO:0048662],
striated muscle cell differentiation [GO:0051146],
positive regulation of protein kinase B signaling [GO:0051897],
mammary gland involution [GO:0060056],
response to growth hormone [GO:0060416],
cellular response to cAMP [GO:0071320],
cellular response to organic cyclic compound [GO:0071407],
negative regulation of muscle tissue development [GO:1901862],
negative regulation of skeletal muscle hypertrophy [GO:1904205],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
regulation of growth [GO:0040008],

Molecular Function:
fibronectin binding [GO:0001968],
protein binding [GO:0005515],
insulin-like growth factor I binding [GO:0031994],
insulin-like growth factor II binding [GO:0031995],
insulin-like growth factor binding [GO:0005520],
growth factor binding [GO:0019838],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
insulin-like growth factor binding protein complex [GO:0016942],
insulin-like growth factor ternary complex [GO:0042567],