IGFBP3

insulin like growth factor binding protein 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16626901 HUVEC Human NO
17635417 HUVEC Human, rat NO
18171112 HUVEC Human NO
18329388 WI-38 Human NO
22778398 MCF7 , ZR-75-1, IMR-90, 293T, ARPE-19 Breast Human NO
24960204 Primary fibroblasts derived from ear Mouse NO
29081404 IMR-90 Human NO
29548335 Li Fraumeni Human YES
30370550 Primary cells derived from nucleus pulposus Rat NO
7688372 HDF Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29579543 IMR-90 Human NO

GO terms:

Biological Process:
regulation of cell growth [GO:0001558],
osteoblast differentiation [GO:0001649],
negative regulation of protein phosphorylation [GO:0001933],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
negative regulation of cell proliferation [GO:0008285],
negative regulation of signal transduction [GO:0009968],
regulation of glucose metabolic process [GO:0010906],
negative regulation of smooth muscle cell migration [GO:0014912],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
positive regulation of MAPK cascade [GO:0043410],
regulation of insulin-like growth factor receptor signaling pathway [GO:0043567],
positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568],
regulation of phosphoprotein phosphatase activity [GO:0043666],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
type B pancreatic cell proliferation [GO:0044342],
positive regulation of myoblast differentiation [GO:0045663],
negative regulation of smooth muscle cell proliferation [GO:0048662],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
regulation of growth [GO:0040008],
positive regulation of apoptotic DNA fragmentation [GO:1902512],
negative regulation of testosterone secretion [GO:2000844],

Molecular Function:
fibronectin binding [GO:0001968],
protein binding [GO:0005515],
insulin-like growth factor binding [GO:0005520],
protein tyrosine phosphatase activator activity [GO:0008160],
insulin-like growth factor I binding [GO:0031994],
insulin-like growth factor II binding [GO:0031995],
metal ion binding [GO:0046872],
growth factor binding [GO:0019838],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
endoplasmic reticulum lumen [GO:0005788],
insulin-like growth factor binding protein complex [GO:0016942],
insulin-like growth factor ternary complex [GO:0042567],
nuclear heterochromatin [GO:0005720],
platelet alpha granule [GO:0031091],
insulin-like growth factor binary complex [GO:0042568],