IFNG

interferon gamma

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19071156 HUVEC Human NO
25982278 HeLa, MCF7, TC-1, B16 Human, Mouse NO
28791835 MSC Bone marrow Mouse NO
29796172 SK-BR-3, BT-474, MCF7, T-47D, HCC-1419, MDA-MB-231, MDA-MB-469 Human NO
30226595 B16 Mouse NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
positive regulation of protein phosphorylation [GO:0001934],
adaptive immune response [GO:0002250],
apoptotic process [GO:0006915],
humoral immune response [GO:0006959],
cell cycle arrest [GO:0007050],
cell surface receptor signaling pathway [GO:0007166],
positive regulation of cell proliferation [GO:0008284],
response to virus [GO:0009615],
regulation of receptor activity [GO:0010469],
positive regulation of autophagy [GO:0010508],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of epithelial cell migration [GO:0010634],
regulation of protein ADP-ribosylation [GO:0010835],
negative regulation of epithelial cell differentiation [GO:0030857],
positive regulation of protein complex assembly [GO:0031334],
negative regulation of interleukin-17 production [GO:0032700],
positive regulation of interleukin-12 production [GO:0032735],
positive regulation of interleukin-23 production [GO:0032747],
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [GO:0032834],
positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141],
positive regulation of smooth muscle cell apoptotic process [GO:0034393],
interleukin-12-mediated signaling pathway [GO:0035722],
regulation of growth [GO:0040008],
positive regulation of protein import into nucleus [GO:0042307],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
regulation of regulatory T cell differentiation [GO:0045589],
positive regulation of osteoclast differentiation [GO:0045672],
negative regulation of transcription, DNA-templated [GO:0045892],
negative regulation of smooth muscle cell proliferation [GO:0048662],
regulation of insulin secretion [GO:0050796],
positive regulation of membrane protein ectodomain proteolysis [GO:0051044],
defense response to virus [GO:0051607],
positive regulation of killing of cells of other organism [GO:0051712],
interferon-gamma-mediated signaling pathway [GO:0060333],
regulation of interferon-gamma-mediated signaling pathway [GO:0060334],
positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity [GO:0060550],
positive regulation of fructose 1,6-bisphosphate metabolic process [GO:0060552],
positive regulation of vitamin D biosynthetic process [GO:0060557],
positive regulation of calcidiol 1-monooxygenase activity [GO:0060559],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
positive regulation of protein deacetylation [GO:0090312],
extrinsic apoptotic signaling pathway [GO:0097191],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of exosomal secretion [GO:1903543],
positive regulation of core promoter binding [GO:1904798],
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309],
neutrophil apoptotic process [GO:0001781],
regulation of the force of heart contraction [GO:0002026],
CD8-positive, alpha-beta T cell differentiation involved in immune response [GO:0002302],
regulation of transcription, DNA-templated [GO:0006355],
inflammatory cell apoptotic process [GO:0006925],
immune response [GO:0006955],
negative regulation of cell proliferation [GO:0008285],
antigen processing and presentation [GO:0019882],
neutrophil chemotaxis [GO:0030593],
endoplasmic reticulum unfolded protein response [GO:0030968],
negative regulation of myelination [GO:0031642],
positive regulation of synaptic transmission, cholinergic [GO:0032224],
positive regulation of tumor necrosis factor production [GO:0032760],
positive regulation of T cell proliferation [GO:0042102],
defense response to bacterium [GO:0042742],
defense response to protozoan [GO:0042832],
positive regulation of apoptotic process [GO:0043065],
negative regulation of growth of symbiont in host [GO:0044130],
negative regulation of growth of symbiont involved in interaction with host [GO:0044146],
positive regulation of chemokine biosynthetic process [GO:0045080],
positive regulation of interleukin-12 biosynthetic process [GO:0045084],
positive regulation of MHC class II biosynthetic process [GO:0045348],
positive regulation of interleukin-6 biosynthetic process [GO:0045410],
positive regulation of neuron differentiation [GO:0045666],
negative regulation of osteoclast differentiation [GO:0045671],
positive regulation of cell adhesion [GO:0045785],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of fibroblast proliferation [GO:0048147],
positive regulation of isotype switching to IgG isotypes [GO:0048304],
regulation of defense response to virus by host [GO:0050691],
positive regulation of interleukin-1 beta secretion [GO:0050718],
regulation of immune response [GO:0050776],
T cell receptor signaling pathway [GO:0050852],
sensory perception of mechanical stimulus [GO:0050954],
regulation of glial cell proliferation [GO:0060251],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interleukin-18 [GO:0071351],
negative regulation of glomerular mesangial cell proliferation [GO:0072125],
regulation of neuronal action potential [GO:0098908],
regulation of hepatocyte proliferation [GO:2000345],

Molecular Function:
cytokine activity [GO:0005125],
interferon-gamma receptor binding [GO:0005133],
protein binding [GO:0005515],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
external side of plasma membrane [GO:0009897],
neuron projection [GO:0043005],
perikaryon [GO:0043204],