HYAL2

hyaluronidase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
response to reactive oxygen species [GO:0000302],
kidney development [GO:0001822],
hematopoietic progenitor cell differentiation [GO:0002244],
carbohydrate metabolic process [GO:0005975],
glycosaminoglycan catabolic process [GO:0006027],
response to virus [GO:0009615],
multicellular organism aging [GO:0010259],
negative regulation of fibroblast migration [GO:0010764],
fusion of virus membrane with host plasma membrane [GO:0019064],
transformation of host cell by virus [GO:0019087],
hyaluronan catabolic process [GO:0030214],
negative regulation of cell growth [GO:0030308],
positive regulation of urine volume [GO:0035810],
monocyte activation [GO:0042117],
positive regulation of protein import into nucleus [GO:0042307],
negative regulation of MAP kinase activity [GO:0043407],
cellular response to fibroblast growth factor stimulus [GO:0044344],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
response to antibiotic [GO:0046677],
viral entry into host cell [GO:0046718],
skeletal system morphogenesis [GO:0048705],
positive regulation of inflammatory response [GO:0050729],
cartilage development [GO:0051216],
defense response to virus [GO:0051607],
negative regulation of protein kinase B signaling [GO:0051898],
multicellular organismal iron ion homeostasis [GO:0060586],
negative regulation of protein tyrosine kinase activity [GO:0061099],
renal water absorption [GO:0070295],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to UV-B [GO:0071493],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of interleukin-8 secretion [GO:2000484],
positive regulation of interleukin-6 secretion [GO:2000778],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
metabolic process [GO:0008152],

Molecular Function:
virus receptor activity [GO:0001618],
transcription coactivator activity [GO:0003713],
hyalurononglucosaminidase activity [GO:0004415],
protein binding [GO:0005515],
hyaluronic acid binding [GO:0005540],
enzyme binding [GO:0019899],
receptor signaling protein tyrosine kinase inhibitor activity [GO:0030294],
receptor tyrosine kinase binding [GO:0030971],
hyaluronoglucuronidase activity [GO:0033906],
transforming growth factor beta binding [GO:0050431],
catalytic activity [GO:0003824],
hydrolase activity [GO:0016787],
hydrolase activity, acting on glycosyl bonds [GO:0016798],

Cellular Component:
Golgi membrane [GO:0000139],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
microvillus [GO:0005902],
cell surface [GO:0009986],
apical plasma membrane [GO:0016324],
endocytic vesicle [GO:0030139],
anchored component of external side of plasma membrane [GO:0031362],
cytoplasmic vesicle [GO:0031410],
membrane raft [GO:0045121],
anchored component of plasma membrane [GO:0046658],
perinuclear region of cytoplasm [GO:0048471],
RNA polymerase II transcription factor complex [GO:0090575],
membrane [GO:0016020],
anchored component of membrane [GO:0031225],