ANXA2

annexin A2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
membrane raft assembly [GO:0001765],
positive regulation of receptor recycling [GO:0001921],
positive regulation of protein phosphorylation [GO:0001934],
growth plate cartilage development [GO:0003417],
membrane budding [GO:0006900],
body fluid secretion [GO:0007589],
regulation of plasminogen activation [GO:0010755],
collagen fibril organization [GO:0030199],
biomineral tissue development [GO:0031214],
positive regulation of vesicle fusion [GO:0031340],
positive regulation of chondrocyte differentiation [GO:0032332],
negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804],
interleukin-12-mediated signaling pathway [GO:0035722],
osteoclast development [GO:0036035],
fibrinolysis [GO:0042730],
negative regulation of catalytic activity [GO:0043086],
neutrophil degranulation [GO:0043312],
positive regulation of vacuole organization [GO:0044090],
negative regulation of development of symbiont involved in interaction with host [GO:0044147],
positive regulation by host of viral process [GO:0044794],
positive regulation of fibroblast proliferation [GO:0048146],
protein heterotetramerization [GO:0051290],
regulation of cytosolic calcium ion concentration [GO:0051480],
positive regulation of calcium ion transport [GO:0051928],
catabolism by host of symbiont protein [GO:0052362],
negative regulation by host of symbiont molecular function [GO:0052405],
endocardial cell differentiation [GO:0060956],
calcium ion transmembrane transport [GO:0070588],
protein localization to plasma membrane [GO:0072659],
response to thyroid hormone [GO:0097066],
cell-cell adhesion [GO:0098609],
positive regulation of viral life cycle [GO:1903902],
positive regulation of low-density lipoprotein particle clearance [GO:1905581],
positive regulation of binding [GO:0051099],

Molecular Function:
phosphatidylserine binding [GO:0001786],
protease binding [GO:0002020],
RNA binding [GO:0003723],
calcium channel activity [GO:0005262],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
calcium-dependent phospholipid binding [GO:0005544],
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546],
cytoskeletal protein binding [GO:0008092],
Rab GTPase binding [GO:0017137],
phospholipase A2 inhibitor activity [GO:0019834],
identical protein binding [GO:0042802],
S100 protein binding [GO:0044548],
bone sialoprotein binding [GO:0044730],
virion binding [GO:0046790],
calcium-dependent protein binding [GO:0048306],
cadherin binding involved in cell-cell adhesion [GO:0098641],
molecular function regulator [GO:0098772],
voltage-gated calcium channel activity involved in regulation of cytosolic calcium ion concentration [GO:0099511],
phospholipase inhibitor activity [GO:0004859],

Cellular Component:
ruffle [GO:0001726],
extracellular region [GO:0005576],
basement membrane [GO:0005604],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lysosomal membrane [GO:0005765],
endosome [GO:0005768],
early endosome [GO:0005769],
lipid particle [GO:0005811],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell adherens junction [GO:0005913],
cell cortex [GO:0005938],
cell surface [GO:0009986],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
extrinsic component of plasma membrane [GO:0019897],
midbody [GO:0030496],
late endosome membrane [GO:0031902],
vesicle [GO:0031982],
azurophil granule lumen [GO:0035578],
myelin sheath adaxonal region [GO:0035749],
sarcolemma [GO:0042383],
melanosome [GO:0042470],
Schmidt-Lanterman incisure [GO:0043220],
macropinosome [GO:0044354],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
PCSK9-AnxA2 complex [GO:1990667],
stress fiber [GO:0001725],
cell junction [GO:0030054],
macromolecular complex [GO:0032991],