anoctamin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
cation transport [GO:0006812],
chloride transport [GO:0006821],
phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200],
multicellular organism development [GO:0007275],
iodide transport [GO:0015705],
ion transmembrane transport [GO:0034220],
cellular response to heat [GO:0034605],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
detection of temperature stimulus involved in sensory perception of pain [GO:0050965],
chloride transmembrane transport [GO:1902476],
ion transport [GO:0006811],
regulation of membrane potential [GO:0042391],
detection of mechanical stimulus involved in sensory perception of pain [GO:0050966],
trachea development [GO:0060438],

Molecular Function:
calcium activated cation channel activity [GO:0005227],
intracellular calcium activated chloride channel activity [GO:0005229],
voltage-gated chloride channel activity [GO:0005247],
chloride channel activity [GO:0005254],
protein binding [GO:0005515],
iodide transmembrane transporter activity [GO:0015111],
protein dimerization activity [GO:0046983],
phospholipid scramblase activity [GO:0017128],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],

Cellular Component:
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
apical plasma membrane [GO:0016324],
chloride channel complex [GO:0034707],
extracellular exosome [GO:0070062],
external side of plasma membrane [GO:0009897],
membrane [GO:0016020],
integral component of membrane [GO:0016021],