HAS2

hyaluronan synthase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25264594 Primary fibroblasts derived from skin Human, mouse NO
27339908 Primary mesenchymal stem cells derived from adipose tissue Human NO

GO terms:

Biological Process:
vasculogenesis [GO:0001570],
kidney development [GO:0001822],
positive regulation of cell proliferation [GO:0008284],
positive regulation of keratinocyte proliferation [GO:0010838],
positive regulation of smooth muscle cell migration [GO:0014911],
hyaluronan biosynthetic process [GO:0030213],
positive regulation of cell migration [GO:0030335],
positive regulation of urine volume [GO:0035810],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
atrioventricular canal development [GO:0036302],
estrous cycle [GO:0044849],
extracellular polysaccharide biosynthetic process [GO:0045226],
positive regulation of keratinocyte migration [GO:0051549],
bone morphogenesis [GO:0060349],
renal water absorption [GO:0070295],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to fluid shear stress [GO:0071498],
extracellular matrix assembly [GO:0085029],
endocardial cushion to mesenchymal transition [GO:0090500],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
positive regulation of hyaluronan biosynthetic process [GO:1900127],
positive regulation of monocyte aggregation [GO:1900625],
regulation of extracellular matrix assembly [GO:1901201],
hyaluronan metabolic process [GO:0030212],

Molecular Function:
protein binding [GO:0005515],
identical protein binding [GO:0042802],
hyaluronan synthase activity [GO:0050501],
transferase activity [GO:0016740],
transferase activity, transferring glycosyl groups [GO:0016757],

Cellular Component:
cytoplasm [GO:0005737],
integral component of plasma membrane [GO:0005887],
plasma membrane raft [GO:0044853],
membrane [GO:0016020],
integral component of membrane [GO:0016021],