GPLD1

glycosylphosphatidylinositol specific phospholipase D1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
ossification [GO:0001503],
cell migration involved in sprouting angiogenesis [GO:0002042],
chondrocyte differentiation [GO:0002062],
complement receptor mediated signaling pathway [GO:0002430],
C-terminal protein lipidation [GO:0006501],
GPI anchor release [GO:0006507],
negative regulation of cell proliferation [GO:0008285],
insulin receptor signaling pathway [GO:0008286],
response to glucose [GO:0009749],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of alkaline phosphatase activity [GO:0010694],
positive regulation of triglyceride biosynthetic process [GO:0010867],
negative regulation of triglyceride catabolic process [GO:0010897],
positive regulation of glucose metabolic process [GO:0010907],
positive regulation of high-density lipoprotein particle clearance [GO:0010983],
cellular response to insulin stimulus [GO:0032869],
cellular response to drug [GO:0035690],
hematopoietic stem cell migration [GO:0035701],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
positive regulation of apoptotic process [GO:0043065],
positive regulation of cytolysis [GO:0045919],
phosphatidylcholine metabolic process [GO:0046470],
positive regulation of membrane protein ectodomain proteolysis [GO:0051044],
positive regulation of secretion [GO:0051047],
transepithelial transport [GO:0070633],
cellular response to calcium ion [GO:0071277],
cellular response to cholesterol [GO:0071397],
cellular response to triglyceride [GO:0071401],
cellular response to pH [GO:0071467],
hematopoietic stem cell migration to bone marrow [GO:0097241],
regulation of cellular response to insulin stimulus [GO:1900076],
cellular response to inorganic substance [GO:0071241],
cellular response to iron(II) ion [GO:0071282],

Molecular Function:
glycosylphosphatidylinositol phospholipase D activity [GO:0004621],
phospholipase D activity [GO:0004630],
sodium channel regulator activity [GO:0017080],
protein binding [GO:0005515],
hydrolase activity [GO:0016787],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
lysosomal membrane [GO:0005765],
extracellular matrix [GO:0031012],
intracellular membrane-bounded organelle [GO:0043231],
extracellular exosome [GO:0070062],
high-density lipoprotein particle [GO:0034364],