AMBRA1

autophagy and beclin 1 regulator 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27191270 Primary fibroblasts derived from skin Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA486 Skin, Lung Human YES

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
mitophagy [GO:0000422],
macromitophagy [GO:0000423],
autophagy [GO:0006914],
negative regulation of cell proliferation [GO:0008285],
cellular response to starvation [GO:0009267],
positive regulation of autophagy [GO:0010508],
negative regulation of cardiac muscle cell apoptotic process [GO:0010667],
macroautophagy [GO:0016236],
neural tube development [GO:0021915],
cell differentiation [GO:0030154],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
response to mitochondrial depolarisation [GO:0098780],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],

Molecular Function:
protein binding [GO:0005515],
ubiquitin protein ligase binding [GO:0031625],
GTPase binding [GO:0051020],

Cellular Component:
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
autophagosome [GO:0005776],
cytosol [GO:0005829],
axoneme [GO:0005930],
phagocytic vesicle [GO:0045335],
perinuclear region of cytoplasm [GO:0048471],
cytoplasmic vesicle [GO:0031410],