ABCB4

ATP binding cassette subfamily B member 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
lipid metabolic process [GO:0006629],
regulation of lipid metabolic process [GO:0019216],
positive regulation of cholesterol transport [GO:0032376],
bile acid secretion [GO:0032782],
response to drug [GO:0042493],
phospholipid translocation [GO:0045332],
transmembrane transport [GO:0055085],
lipid homeostasis [GO:0055088],
positive regulation of phospholipid translocation [GO:0061092],
ceramide translocation [GO:0099040],
response to fenofibrate [GO:1901557],
cellular response to bile acid [GO:1903413],
positive regulation of phospholipid transport [GO:2001140],
drug transmembrane transport [GO:0006855],
lipid transport [GO:0006869],

Molecular Function:
protein binding [GO:0005515],
ATP binding [GO:0005524],
phospholipid transporter activity [GO:0005548],
phosphatidylcholine transporter activity [GO:0008525],
ATPase activity, coupled to transmembrane movement of substances [GO:0042626],
phosphatidylcholine-translocating ATPase activity [GO:0090554],
ceramide-translocating ATPase activity [GO:0099038],
nucleotide binding [GO:0000166],
ATPase activity [GO:0016887],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
apical plasma membrane [GO:0016324],
clathrin-coated vesicle [GO:0030136],
membrane raft [GO:0045121],
intercellular canaliculus [GO:0046581],
extracellular exosome [GO:0070062],
Golgi membrane [GO:0000139],
cytoplasmic vesicle [GO:0031410],