ALOX5

arachidonate 5-lipoxygenase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15616590 IMR-90, LF1, WI-38, MEF Human, mouse NO

GO terms:

Biological Process:
leukotriene production involved in inflammatory response [GO:0002540],
leukotriene metabolic process [GO:0006691],
cytokine-mediated signaling pathway [GO:0019221],
leukotriene biosynthetic process [GO:0019370],
lipoxygenase pathway [GO:0019372],
interleukin-18-mediated signaling pathway [GO:0035655],
long-chain fatty acid biosynthetic process [GO:0042759],
neutrophil degranulation [GO:0043312],
oxidation-reduction process [GO:0055114],
lipoxin biosynthetic process [GO:2001301],
acute inflammatory response [GO:0002526],
inflammatory response [GO:0006954],
sensory perception of pain [GO:0019233],
positive regulation of vasoconstriction [GO:0045907],
positive regulation of cytochrome-c oxidase activity [GO:1904960],

Molecular Function:
arachidonate 5-lipoxygenase activity [GO:0004051],
iron ion binding [GO:0005506],
protein binding [GO:0005515],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702],
metal ion binding [GO:0046872],
dioxygenase activity [GO:0051213],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nuclear envelope [GO:0005635],
nuclear envelope lumen [GO:0005641],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
nuclear matrix [GO:0016363],
nuclear membrane [GO:0031965],
secretory granule lumen [GO:0034774],
ficolin-1-rich granule lumen [GO:1904813],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
membrane [GO:0016020],
dendrite [GO:0030425],
sarcolemma [GO:0042383],