ALKBH8

alkB homolog 8, tRNA methyltransferase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA223 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
tRNA wobble uridine modification [GO:0002098],
cellular response to DNA damage stimulus [GO:0006974],
metabolic process [GO:0008152],
tRNA methylation [GO:0030488],
methylation [GO:0032259],
oxidation-reduction process [GO:0055114],

Molecular Function:
tRNA binding [GO:0000049],
nucleic acid binding [GO:0003676],
RNA binding [GO:0003723],
catalytic activity [GO:0003824],
iron ion binding [GO:0005506],
methyltransferase activity [GO:0008168],
zinc ion binding [GO:0008270],
tRNA (uracil) methyltransferase activity [GO:0016300],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [GO:0016706],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],
protein binding [GO:0005515],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
nuclear body [GO:0016604],