ALK

ALK receptor tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21518927 MEF, U2OS, ALCL Human NO

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
signal transduction [GO:0007165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
cell proliferation [GO:0008283],
phosphorylation [GO:0016310],
peptidyl-tyrosine phosphorylation [GO:0018108],
hippocampus development [GO:0021766],
adult behavior [GO:0030534],
swimming behavior [GO:0036269],
NIK/NF-kappaB signaling [GO:0038061],
regulation of cell proliferation [GO:0042127],
regulation of apoptotic process [GO:0042981],
regulation of neuron differentiation [GO:0045664],
protein autophosphorylation [GO:0046777],
neuron development [GO:0048666],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
regulation of dopamine receptor signaling pathway [GO:0060159],
response to environmental enrichment [GO:0090648],
protein phosphorylation [GO:0006468],
nervous system development [GO:0007399],
brain development [GO:0007420],

Molecular Function:
NF-kappaB-inducing kinase activity [GO:0004704],
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
protein binding [GO:0005515],
ATP binding [GO:0005524],
identical protein binding [GO:0042802],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
macromolecular complex [GO:0032991],
receptor complex [GO:0043235],
extracellular exosome [GO:0070062],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
axon [GO:0030424],
cell body [GO:0044297],