ESR1

estrogen receptor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
11781307 NIH/3T3 Mouse NO
20585577  T-47D, BT-474, ZR-75-1, MCF7, CAMA-1 Breast Human NO
27259243 HMEC Human NO
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
antral ovarian follicle growth [GO:0001547],
epithelial cell development [GO:0002064],
chromatin remodeling [GO:0006338],
transcription, DNA-templated [GO:0006351],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription from RNA polymerase II promoter [GO:0006366],
transcription initiation from RNA polymerase II promoter [GO:0006367],
signal transduction [GO:0007165],
phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
androgen metabolic process [GO:0008209],
male gonad development [GO:0008584],
negative regulation of gene expression [GO:0010629],
positive regulation of phospholipase C activity [GO:0010863],
protein deubiquitination [GO:0016579],
regulation of Wnt signaling pathway [GO:0030111],
intracellular steroid hormone receptor signaling pathway [GO:0030518],
intracellular estrogen receptor signaling pathway [GO:0030520],
response to estradiol [GO:0032355],
regulation of intracellular estrogen receptor signaling pathway [GO:0033146],
regulation of toll-like receptor signaling pathway [GO:0034121],
regulation of apoptotic process [GO:0042981],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433],
response to estrogen [GO:0043627],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of fibroblast proliferation [GO:0048146],
stem cell differentiation [GO:0048863],
regulation of inflammatory response [GO:0050727],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of protein kinase B signaling [GO:0051897],
uterus development [GO:0060065],
vagina development [GO:0060068],
prostate epithelial cord elongation [GO:0060523],
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527],
regulation of branching involved in prostate gland morphogenesis [GO:0060687],
mammary gland branching involved in pregnancy [GO:0060745],
mammary gland alveolus development [GO:0060749],
epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750],
protein localization to chromatin [GO:0071168],
cellular response to estrogen stimulus [GO:0071391],
cellular response to estradiol stimulus [GO:0071392],
negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799],
steroid hormone mediated signaling pathway [GO:0043401],
regulation of neuron apoptotic process [GO:0043523],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742],
negative regulation of mitotic nuclear division [GO:0045839],
negative regulation of glucose import [GO:0046325],
negative regulation of smooth muscle cell proliferation [GO:0048662],
positive regulation of epithelial cell proliferation [GO:0050679],
positive regulation of nitric-oxide synthase activity [GO:0051000],
Sertoli cell proliferation [GO:0060011],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
negative regulation of triglyceride metabolic process [GO:0090209],
negative regulation of neuron death [GO:1901215],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
TFIIB-class transcription factor binding [GO:0001093],
transcription coactivator binding [GO:0001223],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879],
steroid binding [GO:0005496],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
transcription factor binding [GO:0008134],
zinc ion binding [GO:0008270],
TBP-class protein binding [GO:0017025],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
nitric-oxide synthase regulator activity [GO:0030235],
estrogen receptor activity [GO:0030284],
estrogen receptor binding [GO:0030331],
estrogen response element binding [GO:0034056],
identical protein binding [GO:0042802],
ATPase binding [GO:0051117],
DNA binding [GO:0003677],
steroid hormone receptor activity [GO:0003707],
lipid binding [GO:0008289],
type 1 metabotropic glutamate receptor binding [GO:0031798],
phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312],
hormone binding [GO:0042562],
sequence-specific DNA binding [GO:0043565],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
promoter-specific chromatin binding [GO:1990841],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
macromolecular complex [GO:0032991],
transcriptionally active chromatin [GO:0035327],
transcriptional preinitiation complex [GO:0097550],
mitochondrion [GO:0005739],
T-tubule [GO:0030315],
neuron projection [GO:0043005],
terminal bouton [GO:0043195],
perikaryon [GO:0043204],
perinuclear region of cytoplasm [GO:0048471],