aldehyde dehydrogenase 1 family member A3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Li Fraumeni Human YES
30626320 HBEC Human NO
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
optic cup morphogenesis involved in camera-type eye development [GO:0002072],
retinoic acid biosynthetic process [GO:0002138],
locomotory behavior [GO:0007626],
nucleus accumbens development [GO:0021768],
embryonic camera-type eye development [GO:0031076],
inner ear morphogenesis [GO:0042472],
retinol metabolic process [GO:0042572],
retinoic acid metabolic process [GO:0042573],
retinal metabolic process [GO:0042574],
positive regulation of apoptotic process [GO:0043065],
embryonic eye morphogenesis [GO:0048048],
neuromuscular process controlling balance [GO:0050885],
protein homotetramerization [GO:0051289],
oxidation-reduction process [GO:0055114],
righting reflex [GO:0060013],
olfactory pit development [GO:0060166],
face development [GO:0060324],
Harderian gland development [GO:0070384],
cellular aldehyde metabolic process [GO:0006081],
nose development [GO:0043584],
positive regulation of retinoic acid receptor signaling pathway [GO:0048386],

Molecular Function:
retinal dehydrogenase activity [GO:0001758],
aldehyde dehydrogenase (NAD) activity [GO:0004029],
aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030],
protein homodimerization activity [GO:0042803],
thyroid hormone binding [GO:0070324],
NAD+ binding [GO:0070403],
3-chloroallyl aldehyde dehydrogenase activity [GO:0004028],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
extracellular exosome [GO:0070062],