aldehyde dehydrogenase 1 family member A1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30626320 HBEC Human NO

GO terms:

Biological Process:
retinoid metabolic process [GO:0001523],
ethanol oxidation [GO:0006069],
cellular aldehyde metabolic process [GO:0006081],
retinol metabolic process [GO:0042572],
positive regulation of GTPase activity [GO:0043547],
oxidation-reduction process [GO:0055114],
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624],
optic cup morphogenesis involved in camera-type eye development [GO:0002072],
retinoic acid biosynthetic process [GO:0002138],
response to oxidative stress [GO:0006979],
response to drug [GO:0042493],
retinoic acid metabolic process [GO:0042573],
9-cis-retinoic acid biosynthetic process [GO:0042904],
9-cis-retinoic acid metabolic process [GO:0042905],
positive regulation of apoptotic process [GO:0043065],
response to ethanol [GO:0045471],
embryonic eye morphogenesis [GO:0048048],
protein homotetramerization [GO:0051289],

Molecular Function:
retinal dehydrogenase activity [GO:0001758],
aldehyde dehydrogenase (NAD) activity [GO:0004029],
GTPase activator activity [GO:0005096],
androgen binding [GO:0005497],
benzaldehyde dehydrogenase (NAD+) activity [GO:0018479],
NAD binding [GO:0051287],
3-chloroallyl aldehyde dehydrogenase activity [GO:0004028],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620],
identical protein binding [GO:0042802],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],
nucleus [GO:0005634],