ALAS1

5'-aminolevulinate synthase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
protoporphyrinogen IX biosynthetic process [GO:0006782],
heme biosynthetic process [GO:0006783],
mitochondrion organization [GO:0007005],
regulation of lipid metabolic process [GO:0019216],
porphyrin-containing compound metabolic process [GO:0006778],
biosynthetic process [GO:0009058],
tetrapyrrole biosynthetic process [GO:0033014],

Molecular Function:
5-aminolevulinate synthase activity [GO:0003870],
protein binding [GO:0005515],
pyridoxal phosphate binding [GO:0030170],
identical protein binding [GO:0042802],
catalytic activity [GO:0003824],
transferase activity [GO:0016740],
transferase activity, transferring acyl groups [GO:0016746],

Cellular Component:
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
cytosol [GO:0005829],