ALAD

aminolevulinate dehydratase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
protoporphyrinogen IX biosynthetic process [GO:0006782],
heme biosynthetic process [GO:0006783],
response to oxidative stress [GO:0006979],
response to herbicide [GO:0009635],
response to iron ion [GO:0010039],
response to zinc ion [GO:0010043],
response to aluminum ion [GO:0010044],
response to ionizing radiation [GO:0010212],
response to vitamin B1 [GO:0010266],
response to selenium ion [GO:0010269],
response to activity [GO:0014823],
response to cobalt ion [GO:0032025],
response to lipopolysaccharide [GO:0032496],
response to vitamin E [GO:0033197],
response to amino acid [GO:0043200],
neutrophil degranulation [GO:0043312],
response to ethanol [GO:0045471],
response to arsenic-containing substance [GO:0046685],
response to cadmium ion [GO:0046686],
response to mercury ion [GO:0046689],
protein homooligomerization [GO:0051260],
response to glucocorticoid [GO:0051384],
response to methylmercury [GO:0051597],
response to platinum ion [GO:0070541],
response to fatty acid [GO:0070542],
cellular response to lead ion [GO:0071284],
cellular response to interleukin-4 [GO:0071353],
negative regulation of proteasomal protein catabolic process [GO:1901799],
porphyrin-containing compound biosynthetic process [GO:0006779],
response to nutrient [GO:0007584],
metabolic process [GO:0008152],
response to organic substance [GO:0010033],
response to metal ion [GO:0010038],
tetrapyrrole biosynthetic process [GO:0033014],
response to drug [GO:0042493],

Molecular Function:
catalytic activity [GO:0003824],
porphobilinogen synthase activity [GO:0004655],
zinc ion binding [GO:0008270],
identical protein binding [GO:0042802],
proteasome core complex binding [GO:1904854],
lyase activity [GO:0016829],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
cytosol [GO:0005829],
secretory granule lumen [GO:0034774],
extracellular exosome [GO:0070062],
ficolin-1-rich granule lumen [GO:1904813],
extracellular space [GO:0005615],