ENPP1

ectonucleotide pyrophosphatase/phosphodiesterase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
generation of precursor metabolites and energy [GO:0006091],
riboflavin metabolic process [GO:0006771],
phosphate-containing compound metabolic process [GO:0006796],
receptor-mediated endocytosis [GO:0006898],
immune response [GO:0006955],
nucleoside triphosphate catabolic process [GO:0009143],
negative regulation of cell growth [GO:0030308],
regulation of bone mineralization [GO:0030500],
inorganic diphosphate transport [GO:0030505],
cellular phosphate ion homeostasis [GO:0030643],
sequestering of triglyceride [GO:0030730],
biomineral tissue development [GO:0031214],
negative regulation of protein autophosphorylation [GO:0031953],
cellular response to insulin stimulus [GO:0032869],
negative regulation of fat cell differentiation [GO:0045599],
negative regulation of glycogen biosynthetic process [GO:0045719],
ATP metabolic process [GO:0046034],
negative regulation of glucose import [GO:0046325],
negative regulation of insulin receptor signaling pathway [GO:0046627],
3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427],
nucleic acid phosphodiester bond hydrolysis [GO:0090305],
negative regulation of ossification [GO:0030279],
bone remodeling [GO:0046849],

Molecular Function:
nucleic acid binding [GO:0003676],
exonuclease activity [GO:0004527],
phosphodiesterase I activity [GO:0004528],
nucleotide diphosphatase activity [GO:0004551],
scavenger receptor activity [GO:0005044],
insulin receptor binding [GO:0005158],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
ATP binding [GO:0005524],
zinc ion binding [GO:0008270],
polysaccharide binding [GO:0030247],
NADH pyrophosphatase activity [GO:0035529],
protein homodimerization activity [GO:0042803],
nucleoside-triphosphate diphosphatase activity [GO:0047429],
3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656],
catalytic activity [GO:0003824],
hydrolase activity [GO:0016787],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],

Cellular Component:
extracellular space [GO:0005615],
lysosomal membrane [GO:0005765],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
extracellular region [GO:0005576],
membrane [GO:0016020],
cell projection [GO:0042995],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
cell body [GO:0044297],
synapse [GO:0045202],
apical dendrite [GO:0097440],
basilar dendrite [GO:0097441],