AKT1

AKT serine/threonine kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16339764 EPCs Human NO
19293429 Aorta Mouse NO
21072054 U-87, U251, U373, LN18, LN429 Human NO
21909130 IMR-90  Human NO
23523798 HCT116 Human NO
27619662 VSMCs Muscle Human NO
27702651 A375, 293A, 293T, 293FT, B16, A259, HeLa, U-87 Human NO
28656269 MSCs rat NO
28691365 EJ, H1299, WI-38 Human NO
29224011 HMECs Endothelium Human NO
29991711 HUVEC Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
21191179 B-CPAP Human NO
21474066 IMR-90 Pancreas Human, mouse NO
21881167 MCF7 Human NO
24476133 DD-HLM, primary leiomyoma cells Human NO
25753771 Primary multipotent cells derived from skin Foreskin Human NO
25766527 Aorta Mouse NO
28915637 H929, OCI-MY5, APR1, OPM-2, MEF Human, mouse NO
30742942 MDA-MB-231, MDA-MB-468, BT-549, SK-BR-3, MCF-7, BT474 Breast Human NO

GO terms:

Biological Process:
osteoblast differentiation [GO:0001649],
maternal placenta development [GO:0001893],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of endothelial cell proliferation [GO:0001938],
cell migration involved in sprouting angiogenesis [GO:0002042],
glycogen biosynthetic process [GO:0005978],
regulation of glycogen biosynthetic process [GO:0005979],
glucose metabolic process [GO:0006006],
translation [GO:0006412],
regulation of translation [GO:0006417],
cellular protein modification process [GO:0006464],
protein phosphorylation [GO:0006468],
negative regulation of protein kinase activity [GO:0006469],
protein import into nucleus [GO:0006606],
nitric oxide biosynthetic process [GO:0006809],
activation-induced cell death of T cells [GO:0006924],
inflammatory response [GO:0006954],
cellular response to DNA damage stimulus [GO:0006974],
response to oxidative stress [GO:0006979],
signal transduction [GO:0007165],
epidermal growth factor receptor signaling pathway [GO:0007173],
G-protein coupled receptor signaling pathway [GO:0007186],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
germ cell development [GO:0007281],
aging [GO:0007568],
cell proliferation [GO:0008283],
positive regulation of cell proliferation [GO:0008284],
insulin receptor signaling pathway [GO:0008286],
apoptotic mitochondrial changes [GO:0008637],
carbohydrate transport [GO:0008643],
response to heat [GO:0009408],
negative regulation of autophagy [GO:0010507],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
negative regulation of plasma membrane long-chain fatty acid transport [GO:0010748],
positive regulation of fibroblast migration [GO:0010763],
positive regulation of sodium ion transport [GO:0010765],
positive regulation of glucose metabolic process [GO:0010907],
positive regulation of mitochondrial membrane potential [GO:0010918],
negative regulation of endopeptidase activity [GO:0010951],
regulation of neuron projection development [GO:0010975],
phosphatidylinositol 3-kinase signaling [GO:0014065],
negative regulation of macroautophagy [GO:0016242],
phosphorylation [GO:0016310],
protein ubiquitination [GO:0016567],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
cytokine-mediated signaling pathway [GO:0019221],
spinal cord development [GO:0021510],
cell projection organization [GO:0030030],
cell differentiation [GO:0030154],
protein catabolic process [GO:0030163],
hyaluronan metabolic process [GO:0030212],
positive regulation of cell growth [GO:0030307],
regulation of cell migration [GO:0030334],
endocrine pancreas development [GO:0031018],
T cell costimulation [GO:0031295],
negative regulation of protein ubiquitination [GO:0031397],
regulation of myelination [GO:0031641],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
TOR signaling [GO:0031929],
negative regulation of fatty acid beta-oxidation [GO:0031999],
positive regulation of endodeoxyribonuclease activity [GO:0032079],
negative regulation of protein binding [GO:0032091],
response to food [GO:0032094],
activation of protein kinase B activity [GO:0032148],
positive regulation of cellular protein metabolic process [GO:0032270],
peripheral nervous system myelin maintenance [GO:0032287],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
cellular response to insulin stimulus [GO:0032869],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
response to fluid shear stress [GO:0034405],
cellular response to reactive oxygen species [GO:0034614],
intracellular signal transduction [GO:0035556],
interleukin-18-mediated signaling pathway [GO:0035655],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
NIK/NF-kappaB signaling [GO:0038061],
glucose homeostasis [GO:0042593],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
anoikis [GO:0043276],
regulation of mRNA stability [GO:0043488],
protein kinase B signaling [GO:0043491],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of fat cell differentiation [GO:0045600],
positive regulation of glycogen biosynthetic process [GO:0045725],
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737],
positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742],
negative regulation of Notch signaling pathway [GO:0045746],
negative regulation of cell size [GO:0045792],
negative regulation of proteolysis [GO:0045861],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of vasoconstriction [GO:0045907],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of glucose import [GO:0046326],
negative regulation of JNK cascade [GO:0046329],
positive regulation of organ growth [GO:0046622],
protein autophosphorylation [GO:0046777],
positive regulation of lipid biosynthetic process [GO:0046889],
insulin-like growth factor receptor signaling pathway [GO:0048009],
positive regulation of smooth muscle cell proliferation [GO:0048661],
regulation of nitric-oxide synthase activity [GO:0050999],
positive regulation of nitric-oxide synthase activity [GO:0051000],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
striated muscle cell differentiation [GO:0051146],
cofactor metabolic process [GO:0051186],
negative regulation of protein kinase B signaling [GO:0051898],
excitatory postsynaptic potential [GO:0060079],
response to growth hormone [GO:0060416],
mammary gland epithelial cell differentiation [GO:0060644],
glycogen cell differentiation involved in embryonic placenta development [GO:0060709],
labyrinthine layer blood vessel development [GO:0060716],
response to UV-A [GO:0070141],
cellular response to mechanical stimulus [GO:0071260],
cellular response to cadmium ion [GO:0071276],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to epidermal growth factor stimulus [GO:0071364],
cellular response to prostaglandin E stimulus [GO:0071380],
cellular response to organic cyclic compound [GO:0071407],
cellular response to hypoxia [GO:0071456],
negative regulation of protein serine/threonine kinase activity [GO:0071901],
establishment of protein localization to mitochondrion [GO:0072655],
maintenance of protein location in mitochondrion [GO:0072656],
negative regulation of release of cytochrome c from mitochondria [GO:0090201],
cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011],
execution phase of apoptosis [GO:0097194],
negative regulation of protein kinase activity by protein phosphorylation [GO:0100002],
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087],
positive regulation of protein localization to nucleus [GO:1900182],
negative regulation of neuron death [GO:1901215],
regulation of signal transduction by p53 class mediator [GO:1901796],
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176],
negative regulation of leukocyte cell-cell adhesion [GO:1903038],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of I-kappaB phosphorylation [GO:1903721],
cellular response to nerve growth factor stimulus [GO:1990090],
response to insulin-like growth factor stimulus [GO:1990418],
positive regulation of protein localization to cell surface [GO:2000010],
negative regulation of lymphocyte migration [GO:2000402],
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240],
carbohydrate metabolic process [GO:0005975],
glycogen metabolic process [GO:0005977],
apoptotic process [GO:0006915],
cytoskeleton organization [GO:0007010],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
response to hormone [GO:0009725],
response to organic substance [GO:0010033],
regulation of protein localization [GO:0032880],
cellular response to decreased oxygen levels [GO:0036294],
cellular response to growth factor stimulus [GO:0071363],
cellular response to peptide [GO:1901653],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein serine/threonine/tyrosine kinase activity [GO:0004712],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547],
kinase activity [GO:0016301],
enzyme binding [GO:0019899],
nitric-oxide synthase regulator activity [GO:0030235],
GTPase activating protein binding [GO:0032794],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
phosphatidylinositol-3,4-bisphosphate binding [GO:0043325],
protein phosphatase 2A binding [GO:0051721],
14-3-3 protein binding [GO:0071889],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
spindle [GO:0005819],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
microtubule cytoskeleton [GO:0015630],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],
ciliary basal body [GO:0036064],
postsynapse [GO:0098794],
membrane [GO:0016020],