AKR1C3

aldo-keto reductase family 1 member C3

Link to human ortholog


Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
24929818 NHEK Human NO
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
retinoid metabolic process [GO:0001523],
prostaglandin metabolic process [GO:0006693],
G-protein coupled receptor signaling pathway [GO:0007186],
response to nutrient [GO:0007584],
steroid metabolic process [GO:0008202],
positive regulation of cell proliferation [GO:0008284],
male gonad development [GO:0008584],
cellular response to starvation [GO:0009267],
positive regulation of cell death [GO:0010942],
farnesol catabolic process [GO:0016488],
cyclooxygenase pathway [GO:0019371],
keratinocyte differentiation [GO:0030216],
cellular response to reactive oxygen species [GO:0034614],
progesterone metabolic process [GO:0042448],
retinol metabolic process [GO:0042572],
retinal metabolic process [GO:0042574],
macromolecule metabolic process [GO:0043170],
daunorubicin metabolic process [GO:0044597],
doxorubicin metabolic process [GO:0044598],
regulation of retinoic acid receptor signaling pathway [GO:0048385],
positive regulation of protein kinase B signaling [GO:0051897],
oxidation-reduction process [GO:0055114],
testosterone biosynthetic process [GO:0061370],
renal absorption [GO:0070293],
cellular response to cadmium ion [GO:0071276],
cellular response to calcium ion [GO:0071277],
cellular response to prostaglandin stimulus [GO:0071379],
cellular response to corticosteroid stimulus [GO:0071384],
cellular response to jasmonic acid stimulus [GO:0071395],
cellular response to prostaglandin D stimulus [GO:0071799],
negative regulation of retinoic acid biosynthetic process [GO:1900053],
regulation of testosterone biosynthetic process [GO:2000224],
positive regulation of endothelial cell apoptotic process [GO:2000353],
positive regulation of reactive oxygen species metabolic process [GO:2000379],

Molecular Function:
retinal dehydrogenase activity [GO:0001758],
alditol:NADP+ 1-oxidoreductase activity [GO:0004032],
aldo-keto reductase (NADP) activity [GO:0004033],
retinol dehydrogenase activity [GO:0004745],
alcohol dehydrogenase (NADP+) activity [GO:0008106],
steroid dehydrogenase activity [GO:0016229],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655],
phenanthrene 9,10-monooxygenase activity [GO:0018636],
dihydrotestosterone 17-beta-dehydrogenase activity [GO:0035410],
prostaglandin H2 endoperoxidase reductase activity [GO:0036130],
prostaglandin D2 11-ketoreductase activity [GO:0036131],
geranylgeranyl reductase activity [GO:0045550],
ketoreductase activity [GO:0045703],
prostaglandin-F synthase activity [GO:0047017],
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020],
androsterone dehydrogenase activity [GO:0047023],
testosterone dehydrogenase (NAD+) activity [GO:0047035],
testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045],
ketosteroid monooxygenase activity [GO:0047086],
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115],
indanol dehydrogenase activity [GO:0047718],
delta4-3-oxosteroid 5beta-reductase activity [GO:0047787],
NADP-retinol dehydrogenase activity [GO:0052650],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],