AKR1B1

aldo-keto reductase family 1 member B

Link to human ortholog


Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24244503 Primary follicular keratinocyte derived from hair Hair folicle Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
retinoid metabolic process [GO:0001523],
tissue homeostasis [GO:0001894],
renal water homeostasis [GO:0003091],
carbohydrate metabolic process [GO:0005975],
sorbitol biosynthetic process [GO:0006061],
C21-steroid hormone biosynthetic process [GO:0006700],
response to water deprivation [GO:0009414],
naphthalene metabolic process [GO:0018931],
electron transport chain [GO:0022900],
stress-activated protein kinase signaling cascade [GO:0031098],
regulation of urine volume [GO:0035809],
norepinephrine metabolic process [GO:0042415],
negative regulation of apoptotic process [GO:0043066],
daunorubicin metabolic process [GO:0044597],
doxorubicin metabolic process [GO:0044598],
fructose biosynthetic process [GO:0046370],
positive regulation of JAK-STAT cascade [GO:0046427],
positive regulation of smooth muscle cell proliferation [GO:0048661],
oxidation-reduction process [GO:0055114],
maternal process involved in female pregnancy [GO:0060135],
cellular hyperosmotic salinity response [GO:0071475],
inner medullary collecting duct development [GO:0072061],
metanephric collecting duct development [GO:0072205],
response to thyroid hormone [GO:0097066],
cellular response to methylglyoxal [GO:0097238],
cellular response to peptide [GO:1901653],

Molecular Function:
retinal dehydrogenase activity [GO:0001758],
alditol:NADP+ 1-oxidoreductase activity [GO:0004032],
alcohol dehydrogenase (NADP+) activity [GO:0008106],
electron carrier activity [GO:0009055],
oxidoreductase activity [GO:0016491],
glyceraldehyde oxidoreductase activity [GO:0043795],

Cellular Component:
extracellular space [GO:0005615],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
cell projection cytoplasm [GO:0032838],
paranodal junction [GO:0033010],
mast cell granule [GO:0042629],
Schmidt-Lanterman incisure [GO:0043220],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
Schwann cell microvillus [GO:0097454],