AKAP6

A-kinase anchoring protein 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
action potential [GO:0001508],
protein targeting [GO:0006605],
regulation of protein kinase A signaling [GO:0010738],
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880],
cAMP-mediated signaling [GO:0019933],
positive regulation of cell growth [GO:0030307],
positive regulation of release of sequestered calcium ion into cytosol [GO:0051281],
regulation of membrane repolarization [GO:0060306],
positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316],
positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051],
positive regulation of calcineurin-NFAT signaling cascade [GO:0070886],
cellular response to cAMP [GO:0071320],
cellular response to cytokine stimulus [GO:0071345],
positive regulation of potassium ion transmembrane transport [GO:1901381],
positive regulation of delayed rectifier potassium channel activity [GO:1902261],
positive regulation of protein phosphorylation [GO:0001934],
negative regulation of adenylate cyclase activity [GO:0007194],
cellular protein complex localization [GO:0034629],
positive regulation of translation [GO:0045727],
cellular response to epinephrine stimulus [GO:0071872],
regulation of cardiac muscle cell contraction [GO:0086004],
regulation of relaxation of cardiac muscle [GO:1901897],
positive regulation of cAMP-dependent protein kinase activity [GO:2000481],

Molecular Function:
protein binding [GO:0005515],
adenylate cyclase binding [GO:0008179],
protein kinase A regulatory subunit binding [GO:0034237],
protein anchor [GO:0043495],
ion channel binding [GO:0044325],
protein kinase A binding [GO:0051018],
binding, bridging [GO:0060090],
enzyme binding [GO:0019899],
protein phosphatase 2A binding [GO:0051721],

Cellular Component:
nuclear envelope [GO:0005635],
cytoplasm [GO:0005737],
caveola [GO:0005901],
junctional sarcoplasmic reticulum membrane [GO:0014701],
intercalated disc [GO:0014704],
sarcoplasmic reticulum [GO:0016529],
T-tubule [GO:0030315],
nuclear membrane [GO:0031965],
calcium channel complex [GO:0034704],
perinuclear region of cytoplasm [GO:0048471],
nucleus [GO:0005634],
macromolecular complex [GO:0032991],
sarcolemma [GO:0042383],