AGTR2

angiotensin II receptor type 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
18362223 VSMC Mouse NO

GO terms:

Biological Process:
blood vessel remodeling [GO:0001974],
regulation of systemic arterial blood pressure by circulatory renin-angiotensin [GO:0001991],
renin-angiotensin regulation of aldosterone production [GO:0002018],
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure [GO:0002033],
brain renin-angiotensin system [GO:0002035],
cellular sodium ion homeostasis [GO:0006883],
inflammatory response [GO:0006954],
cell surface receptor signaling pathway [GO:0007166],
G-protein coupled receptor signaling pathway [GO:0007186],
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199],
nitric oxide mediated signal transduction [GO:0007263],
brain development [GO:0007420],
regulation of blood pressure [GO:0008217],
positive regulation of cell proliferation [GO:0008284],
negative regulation of heart rate [GO:0010459],
negative regulation of norepinephrine secretion [GO:0010700],
cerebellar cortex development [GO:0021695],
negative regulation of cell growth [GO:0030308],
negative regulation of icosanoid secretion [GO:0032304],
positive regulation of phosphoprotein phosphatase activity [GO:0032516],
intracellular signal transduction [GO:0035556],
regulation of metanephros size [GO:0035566],
exploration behavior [GO:0035640],
positive regulation of renal sodium excretion [GO:0035815],
aldosterone secretion [GO:0035932],
angiotensin-activated signaling pathway [GO:0038166],
regulation of protein import into nucleus [GO:0042306],
vasodilation [GO:0042311],
dopamine biosynthetic process [GO:0042416],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of transcription, DNA-templated [GO:0045893],
negative regulation of fibroblast proliferation [GO:0048147],
positive regulation of cytokine secretion [GO:0050715],
positive regulation of nitric-oxide synthase activity [GO:0051000],
negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387],
cell growth involved in cardiac muscle cell development [GO:0061049],
cellular response to dexamethasone stimulus [GO:0071549],
positive regulation of metanephric glomerulus development [GO:0072300],
positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190],
negative regulation of receptor activity [GO:2000272],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
signal transduction [GO:0007165],
regulation of apoptotic process [GO:0042981],
negative regulation of neuron apoptotic process [GO:0043524],
kidney morphogenesis [GO:0060993],

Molecular Function:
G-protein coupled receptor activity [GO:0004930],
angiotensin type II receptor activity [GO:0004945],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
receptor antagonist activity [GO:0048019],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
perinuclear region of cytoplasm [GO:0048471],
membrane [GO:0016020],
integral component of membrane [GO:0016021],