AGRN

agrin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
regulation of protein phosphorylation [GO:0001932],
positive regulation of protein phosphorylation [GO:0001934],
plasma membrane organization [GO:0007009],
chemical synaptic transmission [GO:0007268],
multicellular organism development [GO:0007275],
synapse assembly [GO:0007416],
neuromuscular junction development [GO:0007528],
regulation of synaptic growth at neuromuscular junction [GO:0008582],
cell differentiation [GO:0030154],
positive regulation of protein binding [GO:0032092],
regulation of GTPase activity [GO:0043087],
receptor clustering [GO:0043113],
positive regulation of neuron apoptotic process [GO:0043525],
positive regulation of GTPase activity [GO:0043547],
neurotransmitter receptor metabolic process [GO:0045213],
positive regulation of synaptic growth at neuromuscular junction [GO:0045887],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
regulation of synapse organization [GO:0050807],
protein heterotetramerization [GO:0051290],
positive regulation of filopodium assembly [GO:0051491],
regulation of cardiac muscle contraction [GO:0055117],
positive regulation of protein tyrosine kinase activity [GO:0061098],
regulation of microtubule cytoskeleton organization [GO:0070507],
skeletal muscle acetylcholine-gated channel clustering [GO:0071340],
regulation of cardiac muscle cell membrane potential [GO:0086036],
regulation of axon guidance [GO:1902667],
negative regulation of sodium ion export from cell [GO:1903277],
negative regulation of sodium:potassium-exchanging ATPase activity [GO:1903407],
positive regulation of protein geranylgeranylation [GO:2000541],
retinoid metabolic process [GO:0001523],
glycosaminoglycan biosynthetic process [GO:0006024],
glycosaminoglycan catabolic process [GO:0006027],
cytoskeleton organization [GO:0007010],
signal transduction [GO:0007165],
G-protein coupled acetylcholine receptor signaling pathway [GO:0007213],
extracellular matrix organization [GO:0030198],
clustering of voltage-gated sodium channels [GO:0045162],
synapse organization [GO:0050808],

Molecular Function:
dystroglycan binding [GO:0002162],
extracellular matrix structural constituent [GO:0005201],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
acetylcholine receptor regulator activity [GO:0030548],
chondroitin sulfate binding [GO:0035374],
BMP binding [GO:0036122],
ATPase inhibitor activity [GO:0042030],
heparan sulfate proteoglycan binding [GO:0043395],
ion channel binding [GO:0044325],
transforming growth factor beta binding [GO:0050431],
structural constituent of cytoskeleton [GO:0005200],
sialic acid binding [GO:0033691],
laminin binding [GO:0043236],

Cellular Component:
basement membrane [GO:0005604],
extracellular space [GO:0005615],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
sarcolemma [GO:0042383],
synaptic cleft [GO:0043083],
axonal growth cone [GO:0044295],
synapse [GO:0045202],
glutamatergic synapse [GO:0098978],
extracellular region [GO:0005576],
Golgi lumen [GO:0005796],
lysosomal lumen [GO:0043202],
extracellular exosome [GO:0070062],