argonaute RISC catalytic component 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
21241449 Primary stem cells derived from adipose tissue Adipose Human NO
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
translation [GO:0006412],
translational initiation [GO:0006413],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
post-embryonic development [GO:0009791],
RNA secondary structure unwinding [GO:0010501],
miRNA metabolic process [GO:0010586],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
production of siRNA involved in RNA interference [GO:0030422],
gene silencing by RNA [GO:0031047],
pre-miRNA processing [GO:0031054],
siRNA loading onto RISC involved in RNA interference [GO:0035087],
posttranscriptional gene silencing by RNA [GO:0035194],
production of miRNAs involved in gene silencing by miRNA [GO:0035196],
miRNA mediated inhibition of translation [GO:0035278],
mRNA cleavage involved in gene silencing by miRNA [GO:0035279],
miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280],
negative regulation of amyloid precursor protein biosynthetic process [GO:0042985],
positive regulation of angiogenesis [GO:0045766],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of translational initiation [GO:0045947],
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213],
regulation of gene silencing by miRNA [GO:0060964],
RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502],
mRNA cleavage involved in gene silencing by siRNA [GO:0090625],
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153],
positive regulation of trophoblast cell migration [GO:1901165],
regulation of transcription, DNA-templated [GO:0006355],
regulation of translation [GO:0006417],
multicellular organism development [GO:0007275],
cell differentiation [GO:0030154],

Molecular Function:
RNA 7-methylguanosine cap binding [GO:0000340],
RNA polymerase II core binding [GO:0000993],
core promoter binding [GO:0001047],
RNA binding [GO:0003723],
double-stranded RNA binding [GO:0003725],
single-stranded RNA binding [GO:0003727],
translation initiation factor activity [GO:0003743],
endoribonuclease activity [GO:0004521],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
siRNA binding [GO:0035197],
miRNA binding [GO:0035198],
metal ion binding [GO:0046872],
endoribonuclease activity, cleaving siRNA-paired mRNA [GO:0070551],
endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624],
mRNA cap binding [GO:0098808],
nucleic acid binding [GO:0003676],
mRNA binding [GO:0003729],
nuclease activity [GO:0004518],
endonuclease activity [GO:0004519],
hydrolase activity [GO:0016787],

Cellular Component:
cytoplasmic mRNA processing body [GO:0000932],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
polysome [GO:0005844],
mRNA cap binding complex [GO:0005845],
membrane [GO:0016020],
RISC complex [GO:0016442],
cell junction [GO:0030054],
dendrite [GO:0030425],
micro-ribonucleoprotein complex [GO:0035068],
extracellular exosome [GO:0070062],
RISC-loading complex [GO:0070578],
ribonucleoprotein complex [GO:1990904],
mitochondrion [GO:0005739],