AGER

advanced glycosylation end-product specific receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24113348 PTECs Kidney Human, mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
regulation of T cell mediated cytotoxicity [GO:0001914],
positive regulation of protein phosphorylation [GO:0001934],
receptor-mediated endocytosis [GO:0006898],
inflammatory response [GO:0006954],
cell surface receptor signaling pathway [GO:0007166],
learning or memory [GO:0007611],
response to wounding [GO:0009611],
glucose mediated signaling pathway [GO:0010255],
astrocyte development [GO:0014002],
neuron projection development [GO:0031175],
negative regulation of interleukin-10 production [GO:0032693],
positive regulation of interleukin-12 production [GO:0032735],
positive regulation of heterotypic cell-cell adhesion [GO:0034116],
positive regulation of activated T cell proliferation [GO:0042104],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
positive regulation of JUN kinase activity [GO:0043507],
transcytosis [GO:0045056],
positive regulation of chemokine biosynthetic process [GO:0045080],
innate immune response [GO:0045087],
positive regulation of interleukin-6 biosynthetic process [GO:0045410],
positive regulation of JNK cascade [GO:0046330],
regulation of synaptic plasticity [GO:0048167],
positive regulation of interleukin-1 beta biosynthetic process [GO:0050725],
induction of positive chemotaxis [GO:0050930],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
regulation of DNA binding [GO:0051101],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of monocyte chemotactic protein-1 production [GO:0071639],
protein localization to membrane [GO:0072657],
modulation of age-related behavioral decline [GO:0090647],
regulation of long-term synaptic potentiation [GO:1900271],
negative regulation of long-term synaptic potentiation [GO:1900272],
negative regulation of long term synaptic depression [GO:1900453],
regulation of p38MAPK cascade [GO:1900744],
positive regulation of p38MAPK cascade [GO:1900745],
regulation of NIK/NF-kappaB signaling [GO:1901222],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961],
negative regulation of blood circulation [GO:1903523],
positive regulation of microglial cell activation [GO:1903980],
positive regulation of endothelin secretion [GO:1904472],
negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597],
response to beta-amyloid [GO:1904645],
cellular response to beta-amyloid [GO:1904646],
positive regulation of monocyte extravasation [GO:2000439],
regulation of CD4-positive, alpha-beta T cell activation [GO:2000514],
positive regulation of dendritic cell differentiation [GO:2001200],
negative regulation of protein phosphorylation [GO:0001933],
negative regulation of endothelial cell proliferation [GO:0001937],
negative regulation of cell adhesion [GO:0007162],
JAK-STAT cascade [GO:0007259],
positive regulation of autophagy [GO:0010508],
negative regulation of endothelial cell migration [GO:0010596],
positive regulation of gene expression [GO:0010628],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
positive regulation of fibroblast migration [GO:0010763],
positive regulation of smooth muscle cell migration [GO:0014911],
positive regulation of signaling [GO:0023056],
negative regulation of signaling [GO:0023057],
positive regulation of cell migration [GO:0030335],
negative regulation of cell migration [GO:0030336],
negative regulation of collagen biosynthetic process [GO:0032966],
positive regulation of apoptotic process [GO:0043065],
positive regulation of neuron apoptotic process [GO:0043525],
positive regulation of fibroblast proliferation [GO:0048146],
positive regulation of smooth muscle cell proliferation [GO:0048661],
regulation of inflammatory response [GO:0050727],
positive regulation of inflammatory response [GO:0050729],
calcium ion homeostasis [GO:0055074],
positive regulation of phagocytosis, engulfment [GO:0060100],
positive regulation of potassium ion transmembrane transporter activity [GO:1901018],
positive regulation of neuron death [GO:1901216],
negative regulation of advanced glycation end-product receptor activity [GO:1904604],
positive regulation of advanced glycation end-product receptor activity [GO:1904605],
positive regulation of endothelial cell apoptotic process [GO:2000353],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
positive regulation of type B pancreatic cell apoptotic process [GO:2000676],

Molecular Function:
beta-amyloid binding [GO:0001540],
transmembrane signaling receptor activity [GO:0004888],
scavenger receptor activity [GO:0005044],
protein binding [GO:0005515],
signaling receptor activity [GO:0038023],
identical protein binding [GO:0042802],
S100 protein binding [GO:0044548],
macromolecular complex binding [GO:0044877],
advanced glycation end-product receptor activity [GO:0050785],
heparin binding [GO:0008201],
high mobility group box 1 binding [GO:0070379],
advanced glycation end-product binding [GO:1904599],

Cellular Component:
fibrillar center [GO:0001650],
extracellular region [GO:0005576],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
apical plasma membrane [GO:0016324],
cell junction [GO:0030054],
postsynapse [GO:0098794],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
external side of plasma membrane [GO:0009897],
basal plasma membrane [GO:0009925],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
axon [GO:0030424],
neuronal cell body [GO:0043025],