ABCA1

ATP binding cassette subfamily A member 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
24680682 Hom, Het Human NO

GO terms:

Biological Process:
protein lipidation [GO:0006497],
lipid transport [GO:0006869],
phagocytosis, engulfment [GO:0006911],
lysosome organization [GO:0007040],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
response to nutrient [GO:0007584],
cholesterol metabolic process [GO:0008203],
negative regulation of macrophage derived foam cell differentiation [GO:0010745],
positive regulation of cholesterol efflux [GO:0010875],
negative regulation of cholesterol storage [GO:0010887],
endosomal transport [GO:0016197],
regulation of lipid metabolic process [GO:0019216],
intracellular cholesterol transport [GO:0032367],
regulation of Cdc42 protein signal transduction [GO:0032489],
cholesterol efflux [GO:0033344],
phospholipid efflux [GO:0033700],
high-density lipoprotein particle assembly [GO:0034380],
response to laminar fluid shear stress [GO:0034616],
apolipoprotein A-I-mediated signaling pathway [GO:0038027],
response to drug [GO:0042493],
cholesterol homeostasis [GO:0042632],
reverse cholesterol transport [GO:0043691],
phospholipid translocation [GO:0045332],
interleukin-1 beta secretion [GO:0050702],
phospholipid homeostasis [GO:0055091],
platelet dense granule organization [GO:0060155],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to retinoic acid [GO:0071300],
cellular response to cholesterol [GO:0071397],
cellular response to low-density lipoprotein particle stimulus [GO:0071404],
regulation of high-density lipoprotein particle assembly [GO:0090107],
anion transmembrane transport [GO:0098656],
peptide secretion [GO:0002790],
phospholipid transport [GO:0015914],
cholesterol transport [GO:0030301],
lipoprotein metabolic process [GO:0042157],
lipoprotein biosynthetic process [GO:0042158],
transmembrane transport [GO:0055085],
cellular response to high density lipoprotein particle stimulus [GO:0071403],

Molecular Function:
receptor binding [GO:0005102],
lipid transporter activity [GO:0005319],
protein binding [GO:0005515],
ATP binding [GO:0005524],
phospholipid binding [GO:0005543],
phospholipid transporter activity [GO:0005548],
high-density lipoprotein particle binding [GO:0008035],
anion transmembrane transporter activity [GO:0008509],
cholesterol binding [GO:0015485],
ATPase activity [GO:0016887],
cholesterol transporter activity [GO:0017127],
syntaxin binding [GO:0019905],
small GTPase binding [GO:0031267],
apolipoprotein binding [GO:0034185],
apolipoprotein A-I binding [GO:0034186],
apolipoprotein A-I receptor activity [GO:0034188],
ATPase activity, coupled to transmembrane movement of substances [GO:0042626],
ATPase binding [GO:0051117],
phosphatidylcholine-translocating ATPase activity [GO:0090554],
phosphatidylserine-translocating ATPase activity [GO:0090556],
nucleotide binding [GO:0000166],

Cellular Component:
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
endocytic vesicle [GO:0030139],
intracellular membrane-bounded organelle [GO:0043231],
membrane raft [GO:0045121],
phagocytic vesicle [GO:0045335],
perinuclear region of cytoplasm [GO:0048471],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],