ADRA2A

adrenoceptor alpha 2A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
positive regulation of cytokine production [GO:0001819],
regulation of smooth muscle contraction [GO:0006940],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
Ras protein signal transduction [GO:0007265],
Rho protein signal transduction [GO:0007266],
positive regulation of cell proliferation [GO:0008284],
negative regulation of norepinephrine secretion [GO:0010700],
regulation of vasoconstriction [GO:0019229],
actin cytoskeleton organization [GO:0030036],
platelet activation [GO:0030168],
positive regulation of cell migration [GO:0030335],
activation of protein kinase activity [GO:0032147],
activation of protein kinase B activity [GO:0032148],
negative regulation of epinephrine secretion [GO:0032811],
cellular response to hormone stimulus [GO:0032870],
receptor transactivation [GO:0035624],
glucose homeostasis [GO:0042593],
positive regulation of potassium ion transport [GO:0043268],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of epidermal growth factor-activated receptor activity [GO:0045741],
negative regulation of calcium ion-dependent exocytosis [GO:0045955],
negative regulation of insulin secretion [GO:0046676],
regulation of insulin secretion [GO:0050796],
intestinal absorption [GO:0050892],
negative regulation of lipid catabolic process [GO:0050995],
positive regulation of membrane protein ectodomain proteolysis [GO:0051044],
negative regulation of calcium ion transport [GO:0051926],
negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179],
adrenergic receptor signaling pathway [GO:0071875],
adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880],
adenylate cyclase-inhibiting adrenergic receptor signaling pathway [GO:0071881],
phospholipase C-activating adrenergic receptor signaling pathway [GO:0071882],
positive regulation of wound healing [GO:0090303],
negative regulation of calcium ion transmembrane transporter activity [GO:1901020],
acute inflammatory response [GO:0002526],
DNA replication [GO:0006260],
female pregnancy [GO:0007565],
fear response [GO:0042596],
thermoception [GO:0050955],
negative regulation of uterine smooth muscle contraction [GO:0070473],
regulation of synaptic vesicle exocytosis [GO:2000300],

Molecular Function:
adrenergic receptor activity [GO:0004935],
alpha2-adrenergic receptor activity [GO:0004938],
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
alpha-1B adrenergic receptor binding [GO:0031692],
alpha-2C adrenergic receptor binding [GO:0031696],
thioesterase binding [GO:0031996],
heterotrimeric G-protein binding [GO:0032795],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
epinephrine binding [GO:0051379],
norepinephrine binding [GO:0051380],

Cellular Component:
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
basolateral plasma membrane [GO:0016323],
receptor complex [GO:0043235],
neuronal cell body [GO:0043025],
axon terminus [GO:0043679],
synapse [GO:0045202],
glutamatergic synapse [GO:0098978],
GABA-ergic synapse [GO:0098982],
integral component of postsynaptic membrane [GO:0099055],
integral component of presynaptic active zone membrane [GO:0099059],
integral component of postsynaptic density membrane [GO:0099061],