ADIPOQ

adiponectin, C1Q and collagen domain containing

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27092462 PancO2, SL4, HUVEC Liver Human, mouse NO
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
20802255 Isolated EPC from Adiponectin knockout db/db diabetic mice Mouse NO
27349869 Primary keratinocytes Human NO
28963101 Artery Human NO

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
positive regulation of protein phosphorylation [GO:0001934],
glucose metabolic process [GO:0006006],
generation of precursor metabolites and energy [GO:0006091],
fatty acid beta-oxidation [GO:0006635],
response to nutrient [GO:0007584],
circadian rhythm [GO:0007623],
response to bacterium [GO:0009617],
response to sucrose [GO:0009744],
response to glucose [GO:0009749],
positive regulation of signal transduction [GO:0009967],
regulation of receptor activity [GO:0010469],
negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642],
positive regulation of protein kinase A signaling [GO:0010739],
negative regulation of macrophage derived foam cell differentiation [GO:0010745],
negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804],
positive regulation of cholesterol efflux [GO:0010875],
regulation of glucose metabolic process [GO:0010906],
response to activity [GO:0014823],
fatty acid oxidation [GO:0019395],
negative regulation of cell migration [GO:0030336],
negative regulation of granulocyte differentiation [GO:0030853],
negative regulation of protein autophosphorylation [GO:0031953],
positive regulation of cellular protein metabolic process [GO:0032270],
negative regulation of tumor necrosis factor production [GO:0032720],
positive regulation of interleukin-8 production [GO:0032757],
cellular response to insulin stimulus [GO:0032869],
positive regulation of myeloid cell apoptotic process [GO:0033034],
negative regulation of heterotypic cell-cell adhesion [GO:0034115],
low-density lipoprotein particle clearance [GO:0034383],
response to tumor necrosis factor [GO:0034612],
cellular response to drug [GO:0035690],
regulation of fatty acid biosynthetic process [GO:0042304],
glucose homeostasis [GO:0042593],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
negative regulation of MAP kinase activity [GO:0043407],
response to ethanol [GO:0045471],
negative regulation of fat cell differentiation [GO:0045599],
negative regulation of macrophage differentiation [GO:0045650],
negative regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045715],
negative regulation of gluconeogenesis [GO:0045721],
negative regulation of blood pressure [GO:0045776],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of fatty acid metabolic process [GO:0045923],
positive regulation of glucose import [GO:0046326],
negative regulation of hormone secretion [GO:0046888],
negative regulation of inflammatory response [GO:0050728],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
negative regulation of phagocytosis [GO:0050765],
negative regulation of synaptic transmission [GO:0050805],
brown fat cell differentiation [GO:0050873],
protein homooligomerization [GO:0051260],
response to glucocorticoid [GO:0051384],
protein heterotrimerization [GO:0070208],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
response to linoleic acid [GO:0070543],
detection of oxidative stress [GO:0070994],
cellular response to cAMP [GO:0071320],
positive regulation of monocyte chemotactic protein-1 production [GO:0071639],
cellular response to epinephrine stimulus [GO:0071872],
protein localization to plasma membrane [GO:0072659],
negative regulation of intracellular protein transport [GO:0090317],
negative regulation of receptor binding [GO:1900121],
negative regulation of vascular smooth muscle cell proliferation [GO:1904706],
negative regulation of vascular associated smooth muscle cell migration [GO:1904753],
negative regulation of DNA biosynthetic process [GO:2000279],
positive regulation of glycogen (starch) synthase activity [GO:2000467],
positive regulation of metanephric glomerular visceral epithelial cell development [GO:2000478],
positive regulation of cAMP-dependent protein kinase activity [GO:2000481],
positive regulation of renal albumin absorption [GO:2000534],
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584],
negative regulation of metanephric mesenchymal cell migration [GO:2000590],
positive regulation of protein kinase activity [GO:0045860],

Molecular Function:
receptor binding [GO:0005102],
cytokine activity [GO:0005125],
hormone activity [GO:0005179],
extracellular matrix structural constituent [GO:0005201],
protein binding [GO:0005515],
sialic acid binding [GO:0033691],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],

Cellular Component:
extracellular region [GO:0005576],
collagen trimer [GO:0005581],
extracellular space [GO:0005615],
endoplasmic reticulum [GO:0005783],
cell surface [GO:0009986],
macromolecular complex [GO:0032991],