ADCY8

adenylate cyclase 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
renal water homeostasis [GO:0003091],
cAMP biosynthetic process [GO:0006171],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
activation of adenylate cyclase activity [GO:0007190],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
learning or memory [GO:0007611],
memory [GO:0007613],
long-term memory [GO:0007616],
locomotory behavior [GO:0007626],
glucose mediated signaling pathway [GO:0010255],
positive regulation of synaptic plasticity [GO:0031915],
positive regulation of CREB transcription factor activity [GO:0032793],
activation of protein kinase A activity [GO:0034199],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
opioid receptor signaling pathway [GO:0038003],
glucose homeostasis [GO:0042593],
protein oligomerization [GO:0051259],
protein homooligomerization [GO:0051260],
regulation of cytosolic calcium ion concentration [GO:0051480],
cellular response to calcium ion [GO:0071277],
cellular response to morphine [GO:0071315],
cellular response to glucose stimulus [GO:0071333],
cellular response to glucagon stimulus [GO:0071377],
regulation of cellular response to stress [GO:0080135],
positive regulation of long-term synaptic potentiation [GO:1900273],
positive regulation of long term synaptic depression [GO:1900454],
cellular response to forskolin [GO:1904322],
cyclic nucleotide biosynthetic process [GO:0009190],
cAMP-mediated signaling [GO:0019933],
intracellular signal transduction [GO:0035556],
modulation of synaptic transmission [GO:0050804],

Molecular Function:
actin binding [GO:0003779],
adenylate cyclase activity [GO:0004016],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
protein heterodimerization activity [GO:0046982],
protein dimerization activity [GO:0046983],
protein phosphatase 2A binding [GO:0051721],
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
lyase activity [GO:0016829],
phosphorus-oxygen lyase activity [GO:0016849],
phosphatase binding [GO:0019902],
protein N-terminus binding [GO:0047485],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
caveola [GO:0005901],
clathrin-coated pit [GO:0005905],
postsynaptic density [GO:0014069],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
cell junction [GO:0030054],
axon [GO:0030424],
dendrite [GO:0030425],
clathrin-coated vesicle membrane [GO:0030665],
neuronal cell body membrane [GO:0032809],
plasma membrane raft [GO:0044853],
membrane raft [GO:0045121],
postsynaptic membrane [GO:0045211],
presynaptic active zone [GO:0048786],
excitatory synapse [GO:0060076],
glutamatergic synapse [GO:0098978],
integral component of presynaptic membrane [GO:0099056],
integral component of membrane [GO:0016021],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],
synapse [GO:0045202],