ADCY6

adenylate cyclase 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
renal water homeostasis [GO:0003091],
cAMP biosynthetic process [GO:0006171],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
activation of adenylate cyclase activity [GO:0007190],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
dopamine receptor signaling pathway [GO:0007212],
negative regulation of neuron projection development [GO:0010977],
activation of protein kinase A activity [GO:0034199],
negative regulation of urine volume [GO:0035811],
cellular response to glucagon stimulus [GO:0071377],
cellular response to prostaglandin E stimulus [GO:0071380],
cellular response to catecholamine stimulus [GO:0071870],
cellular response to vasopressin [GO:1904117],
cellular response to forskolin [GO:1904322],
cyclic nucleotide biosynthetic process [GO:0009190],
intracellular signal transduction [GO:0035556],
maintenance of protein location in plasma membrane [GO:0072660],

Molecular Function:
adenylate cyclase activity [GO:0004016],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
metal ion binding [GO:0046872],
SNARE binding [GO:0000149],
nucleotide binding [GO:0000166],
receptor binding [GO:0005102],
calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294],
lyase activity [GO:0016829],
phosphorus-oxygen lyase activity [GO:0016849],
scaffold protein binding [GO:0097110],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cilium [GO:0005929],
membrane [GO:0016020],
intrinsic component of plasma membrane [GO:0031226],
stereocilium [GO:0032420],
endosome [GO:0005768],
integral component of membrane [GO:0016021],
microvillus membrane [GO:0031528],
sarcolemma [GO:0042383],
cell projection [GO:0042995],
membrane raft [GO:0045121],