ADCY5

adenylate cyclase 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25077541 MEF Mouse NO
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
adenosine receptor signaling pathway [GO:0001973],
renal water homeostasis [GO:0003091],
cAMP biosynthetic process [GO:0006171],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
activation of adenylate cyclase activity [GO:0007190],
adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
locomotory behavior [GO:0007626],
activation of protein kinase A activity [GO:0034199],
neuromuscular process controlling balance [GO:0050885],
regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178],
cellular response to glucagon stimulus [GO:0071377],
cellular response to forskolin [GO:1904322],
cyclic nucleotide biosynthetic process [GO:0009190],
intracellular signal transduction [GO:0035556],

Molecular Function:
adenylate cyclase activity [GO:0004016],
ATP binding [GO:0005524],
adenylate cyclase binding [GO:0008179],
metal ion binding [GO:0046872],
protein heterodimerization activity [GO:0046982],
scaffold protein binding [GO:0097110],
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294],
lyase activity [GO:0016829],
phosphorus-oxygen lyase activity [GO:0016849],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cilium [GO:0005929],
integral component of membrane [GO:0016021],
intermediate filament cytoskeleton [GO:0045111],
endosome [GO:0005768],
membrane [GO:0016020],
sarcolemma [GO:0042383],
cell projection [GO:0042995],
membrane raft [GO:0045121],