ADCY3

adenylate cyclase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
renal water homeostasis [GO:0003091],
cAMP biosynthetic process [GO:0006171],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
activation of adenylate cyclase activity [GO:0007190],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
single fertilization [GO:0007338],
acrosome reaction [GO:0007340],
sensory perception of smell [GO:0007608],
olfactory learning [GO:0008355],
flagellated sperm motility [GO:0030317],
activation of protein kinase A activity [GO:0034199],
cellular response to glucagon stimulus [GO:0071377],
cellular response to forskolin [GO:1904322],
cyclic nucleotide biosynthetic process [GO:0009190],
intracellular signal transduction [GO:0035556],
response to stimulus [GO:0050896],

Molecular Function:
adenylate cyclase activity [GO:0004016],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294],
lyase activity [GO:0016829],
phosphorus-oxygen lyase activity [GO:0016849],

Cellular Component:
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cilium [GO:0005929],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
nucleus [GO:0005634],
cell projection [GO:0042995],
membrane raft [GO:0045121],