ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28728848 Primary chondrocytes derived from cartillage Human NO

GO terms:

Biological Process:
proteolysis [GO:0006508],
extracellular matrix disassembly [GO:0022617],
defense response to bacterium [GO:0042742],
tooth eruption [GO:0044691],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
integrin binding [GO:0005178],
protein binding [GO:0005515],
heparin binding [GO:0008201],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
extracellular matrix binding [GO:0050840],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
extracellular matrix [GO:0031012],