ADAM10

ADAM metallopeptidase domain 10

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
26071561 J3, U266, ARP, ARK, OPM-2, LP1 Bone marrow Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28437250 bEnd.3 murine brain endothelial cell line Mouse NO

GO terms:

Biological Process:
in utero embryonic development [GO:0001701],
protein phosphorylation [GO:0006468],
membrane protein ectodomain proteolysis [GO:0006509],
negative regulation of cell adhesion [GO:0007162],
Notch signaling pathway [GO:0007219],
integrin-mediated signaling pathway [GO:0007229],
cell-cell signaling [GO:0007267],
spermatogenesis [GO:0007283],
positive regulation of cell proliferation [GO:0008284],
positive regulation of T cell chemotaxis [GO:0010820],
protein processing [GO:0016485],
extracellular matrix disassembly [GO:0022617],
positive regulation of cell growth [GO:0030307],
positive regulation of cell migration [GO:0030335],
beta-amyloid formation [GO:0034205],
response to tumor necrosis factor [GO:0034612],
Notch receptor processing, ligand-dependent [GO:0035333],
monocyte activation [GO:0042117],
positive regulation of apoptotic process [GO:0043065],
neutrophil degranulation [GO:0043312],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
PMA-inducible membrane protein ectodomain proteolysis [GO:0051088],
constitutive protein ectodomain proteolysis [GO:0051089],
regulation of dendritic spine morphogenesis [GO:0061001],
response to antineoplastic agent [GO:0097327],
proteolysis [GO:0006508],
nucleocytoplasmic transport [GO:0006913],
Notch receptor processing [GO:0007220],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
receptor binding [GO:0005102],
integrin binding [GO:0005178],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
SH3 domain binding [GO:0017124],
protein kinase binding [GO:0019901],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
SH2 domain binding [GO:0042169],

Cellular Component:
Golgi membrane [GO:0000139],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endoplasmic reticulum lumen [GO:0005788],
Golgi apparatus [GO:0005794],
Golgi-associated vesicle [GO:0005798],
trans-Golgi network [GO:0005802],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
synaptic vesicle [GO:0008021],
cell surface [GO:0009986],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
specific granule membrane [GO:0035579],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
postsynaptic membrane [GO:0045211],
extracellular exosome [GO:0070062],
tertiary granule membrane [GO:0070821],
perinuclear endoplasmic reticulum [GO:0097038],
tetraspanin-enriched microdomain [GO:0097197],
glutamatergic synapse [GO:0098978],
extracellular space [GO:0005615],
dendrite [GO:0030425],
postsynapse [GO:0098794],