CASP4

caspase 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
inflammatory response [GO:0006954],
innate immune response [GO:0045087],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
intrinsic apoptotic signaling pathway [GO:0097193],
execution phase of apoptosis [GO:0097194],
positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265],
cellular response to beta-amyloid [GO:1904646],
immune system process [GO:0002376],
actin filament organization [GO:0007015],
programmed cell death [GO:0012501],
ectopic germ cell programmed cell death [GO:0035234],
regulation of apoptotic process [GO:0042981],
positive regulation of interleukin-1 beta secretion [GO:0050718],
pyroptosis [GO:0070269],

Molecular Function:
cysteine-type endopeptidase activity [GO:0004197],
CARD domain binding [GO:0050700],
cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153],
cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199],
peptidase activity [GO:0008233],
cysteine-type peptidase activity [GO:0008234],
hydrolase activity [GO:0016787],
scaffold protein binding [GO:0097110],

Cellular Component:
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
macromolecular complex [GO:0032991],
inflammasome complex [GO:0061702],
membrane [GO:0016020],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],