caspase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25114039 Primary epithelial cells derived from mammary gland Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
luteolysis [GO:0001554],
neural retina development [GO:0003407],
apoptotic process [GO:0006915],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
brain development [GO:0007420],
aging [GO:0007568],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
protein processing [GO:0016485],
ectopic germ cell programmed cell death [GO:0035234],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
positive regulation of neuron apoptotic process [GO:0043525],
cellular response to mechanical stimulus [GO:0071260],
apoptotic signaling pathway [GO:0097190],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
execution phase of apoptosis [GO:0097194],
positive regulation of apoptotic signaling pathway [GO:2001235],
proteolysis [GO:0006508],

Molecular Function:
cysteine-type endopeptidase activity [GO:0004197],
protein binding [GO:0005515],
enzyme binding [GO:0019899],
protein domain specific binding [GO:0019904],
identical protein binding [GO:0042802],
cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153],
cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200],
peptidase activity [GO:0008233],
cysteine-type peptidase activity [GO:0008234],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
membrane [GO:0016020],