CASP1

caspase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
signal transduction [GO:0007165],
protein autoprocessing [GO:0016540],
cytokine-mediated signaling pathway [GO:0019221],
regulation of apoptotic process [GO:0042981],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
positive regulation of interleukin-1 beta secretion [GO:0050718],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to mechanical stimulus [GO:0071260],
cellular response to organic substance [GO:0071310],
cellular response to cytokine stimulus [GO:0071345],
cellular response to interferon-gamma [GO:0071346],
apoptotic signaling pathway [GO:0097190],
execution phase of apoptosis [GO:0097194],
positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265],
response to hypoxia [GO:0001666],
microglial cell activation [GO:0001774],
myoblast fusion [GO:0007520],
memory [GO:0007613],
response to bacterium [GO:0009617],
regulation of autophagy [GO:0010506],
response to organic cyclic compound [GO:0014070],
protein processing [GO:0016485],
response to lipopolysaccharide [GO:0032496],
interleukin-1 beta production [GO:0032611],
response to ATP [GO:0033198],
response to drug [GO:0042493],
positive regulation of apoptotic process [GO:0043065],
positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010],
positive regulation of cytokine secretion [GO:0050715],
positive regulation of interleukin-1 alpha secretion [GO:0050717],
regulation of inflammatory response [GO:0050727],
mitochondrial depolarization [GO:0051882],
membrane hyperpolarization [GO:0060081],
pyroptosis [GO:0070269],
programmed necrotic cell death [GO:0097300],
toxin transport [GO:1901998],

Molecular Function:
endopeptidase activity [GO:0004175],
cysteine-type endopeptidase activity [GO:0004197],
protein binding [GO:0005515],
cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656],
kinase binding [GO:0019900],
identical protein binding [GO:0042802],
CARD domain binding [GO:0050700],
cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153],
cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199],
peptidase activity [GO:0008233],
cysteine-type peptidase activity [GO:0008234],
hydrolase activity [GO:0016787],
scaffold protein binding [GO:0097110],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],
IPAF inflammasome complex [GO:0072557],
NLRP1 inflammasome complex [GO:0072558],
NLRP3 inflammasome complex [GO:0072559],
AIM2 inflammasome complex [GO:0097169],
protease inhibitor complex [GO:0097179],
extracellular region [GO:0005576],
nucleus [GO:0005634],
neuron projection [GO:0043005],