CASK

calcium/calmodulin dependent serine protein kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
negative regulation of cell-matrix adhesion [GO:0001953],
protein phosphorylation [GO:0006468],
cell adhesion [GO:0007155],
neurotransmitter secretion [GO:0007269],
negative regulation of keratinocyte proliferation [GO:0010839],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
GMP metabolic process [GO:0046037],
GDP metabolic process [GO:0046710],
negative regulation of wound healing [GO:0061045],
calcium ion import [GO:0070509],
positive regulation of calcium ion import [GO:0090280],
negative regulation of cellular response to growth factor stimulus [GO:0090288],
regulation of synaptic vesicle exocytosis [GO:2000300],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
phosphorylation [GO:0016310],
positive regulation of insulin secretion [GO:0032024],
positive regulation of dendritic spine morphogenesis [GO:0061003],
protein localization to plasma membrane [GO:0072659],

Molecular Function:
guanylate kinase activity [GO:0004385],
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
neurexin family protein binding [GO:0042043],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
protein C-terminus binding [GO:0008022],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
PDZ domain binding [GO:0030165],
macromolecular complex binding [GO:0044877],

Cellular Component:
basement membrane [GO:0005604],
nuclear lamina [GO:0005652],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
basolateral plasma membrane [GO:0016323],
nuclear matrix [GO:0016363],
vesicle [GO:0031982],
presynaptic membrane [GO:0042734],
ciliary membrane [GO:0060170],
nucleus [GO:0005634],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
dendrite [GO:0030425],
macromolecular complex [GO:0032991],
neuronal cell body [GO:0043025],
membrane raft [GO:0045121],
synapse [GO:0045202],
synaptic membrane [GO:0097060],
apical dendrite [GO:0097440],
podocyte foot [GO:0098846],