capping protein regulator and myosin 1 linker 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
actin filament organization [GO:0007015],
blood coagulation [GO:0007596],
cell migration [GO:0016477],
lamellipodium assembly [GO:0030032],
positive regulation of cell migration [GO:0030335],
positive regulation of actin filament polymerization [GO:0030838],
ruffle organization [GO:0031529],
macropinocytosis [GO:0044351],
urate metabolic process [GO:0046415],
positive regulation of stress fiber assembly [GO:0051496],
barbed-end actin filament uncapping [GO:0051638],
actin filament network formation [GO:0051639],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
positive regulation of lamellipodium organization [GO:1902745],
negative regulation of barbed-end actin filament capping [GO:2000813],

Molecular Function:
protein binding [GO:0005515],
macromolecular complex binding [GO:0044877],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
nuclear speck [GO:0016607],
lamellipodium [GO:0030027],
cell leading edge [GO:0031252],
filamentous actin [GO:0031941],
macropinosome [GO:0044354],
extracellular exosome [GO:0070062],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
cell projection [GO:0042995],