caspase recruitment domain family member 11

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
positive regulation of cytokine production [GO:0001819],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
immunoglobulin production [GO:0002377],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
B cell differentiation [GO:0030183],
positive regulation of B cell proliferation [GO:0030890],
T cell costimulation [GO:0031295],
Fc-epsilon receptor signaling pathway [GO:0038095],
TORC1 signaling [GO:0038202],
B cell proliferation [GO:0042100],
positive regulation of T cell proliferation [GO:0042102],
regulation of apoptotic process [GO:0042981],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
thymic T cell selection [GO:0045061],
positive regulation of interleukin-2 biosynthetic process [GO:0045086],
regulation of B cell differentiation [GO:0045577],
regulation of T cell differentiation [GO:0045580],
GMP metabolic process [GO:0046037],
GDP metabolic process [GO:0046710],
homeostasis of number of cells [GO:0048872],
T cell receptor signaling pathway [GO:0050852],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
interleukin-2 secretion [GO:0070970],
signal transduction [GO:0007165],
T cell activation [GO:0042110],
lymphocyte activation [GO:0046649],
regulation of immune response [GO:0050776],
positive regulation of T cell activation [GO:0050870],

Molecular Function:
guanylate kinase activity [GO:0004385],
protein binding [GO:0005515],
CARD domain binding [GO:0050700],

Cellular Component:
immunological synapse [GO:0001772],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
CBM complex [GO:0032449],
membrane raft [GO:0045121],
extracellular exosome [GO:0070062],
membrane [GO:0016020],