AARS

alanyl-tRNA synthetase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
tRNA modification [GO:0006400],
tRNA aminoacylation for protein translation [GO:0006418],
alanyl-tRNA aminoacylation [GO:0006419],
tRNA processing [GO:0008033],
cerebellar Purkinje cell layer development [GO:0021680],
negative regulation of neuron apoptotic process [GO:0043524],
neuromuscular process controlling balance [GO:0050885],
translation [GO:0006412],
tRNA aminoacylation [GO:0043039],
neuromuscular process [GO:0050905],

Molecular Function:
tRNA binding [GO:0000049],
aminoacyl-tRNA editing activity [GO:0002161],
Ser-tRNA(Ala) hydrolase activity [GO:0002196],
alanine-tRNA ligase activity [GO:0004813],
ATP binding [GO:0005524],
zinc ion binding [GO:0008270],
amino acid binding [GO:0016597],
translation regulator activity [GO:0045182],
nucleotide binding [GO:0000166],
nucleic acid binding [GO:0003676],
RNA binding [GO:0003723],
aminoacyl-tRNA ligase activity [GO:0004812],
protein binding [GO:0005515],
ligase activity [GO:0016874],
metal ion binding [GO:0046872],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
membrane [GO:0016020],
extracellular exosome [GO:0070062],