CAPN3

calpain 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
apoptotic process [GO:0006915],
muscle organ development [GO:0007517],
positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718],
response to muscle activity [GO:0014850],
protein catabolic process [GO:0030163],
myofibril assembly [GO:0030239],
protein destabilization [GO:0031648],
negative regulation of protein sumoylation [GO:0033234],
negative regulation of apoptotic process [GO:0043066],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
sarcomere organization [GO:0045214],
regulation of myoblast differentiation [GO:0045661],
positive regulation of proteolysis [GO:0045862],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
muscle cell cellular homeostasis [GO:0046716],
regulation of catalytic activity [GO:0050790],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of release of sequestered calcium ion into cytosol [GO:0051281],
response to calcium ion [GO:0051592],
muscle structure development [GO:0061061],
macromolecular complex assembly [GO:0065003],
G1 to G0 transition involved in cell differentiation [GO:0070315],
cellular response to calcium ion [GO:0071277],
cellular response to salt stress [GO:0071472],
protein localization to membrane [GO:0072657],
self proteolysis [GO:0097264],
calcium-dependent self proteolysis [GO:1990092],
programmed cell death [GO:0012501],
sodium-dependent self proteolysis [GO:1990091],
negative regulation of skeletal muscle cell differentiation [GO:2001015],

Molecular Function:
catalytic activity [GO:0003824],
calcium-dependent cysteine-type endopeptidase activity [GO:0004198],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
cysteine-type peptidase activity [GO:0008234],
structural constituent of muscle [GO:0008307],
sodium ion binding [GO:0031402],
titin binding [GO:0031432],
ligase regulator activity [GO:0055103],
binding, bridging [GO:0060090],
receptor binding [GO:0005102],
hydrolase activity [GO:0016787],
enzyme binding [GO:0019899],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
myofibril [GO:0030016],
Z disc [GO:0030018],
T-tubule [GO:0030315],
macromolecular complex [GO:0032991],