ACTR3

actin related protein 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
establishment or maintenance of cell polarity [GO:0007163],
asymmetric cell division [GO:0008356],
meiotic chromosome movement towards spindle pole [GO:0016344],
meiotic cytokinesis [GO:0033206],
Arp2/3 complex-mediated actin nucleation [GO:0034314],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
ephrin receptor signaling pathway [GO:0048013],
spindle localization [GO:0051653],
cilium assembly [GO:0060271],
membrane organization [GO:0061024],
actin polymerization-dependent cell motility [GO:0070358],
cellular response to interferon-gamma [GO:0071346],
actin filament organization [GO:0007015],
positive regulation of lamellipodium assembly [GO:0010592],
positive regulation of fibroblast migration [GO:0010763],
cell projection organization [GO:0030030],
negative regulation of axon extension [GO:0030517],
positive regulation of actin filament polymerization [GO:0030838],
positive regulation of protein binding [GO:0032092],
regulation of myosin II filament organization [GO:0043519],
positive regulation of neuron differentiation [GO:0045666],
astrocyte differentiation [GO:0048708],
positive regulation of astrocyte differentiation [GO:0048711],
positive regulation of dendrite morphogenesis [GO:0050775],
meiotic cell cycle [GO:0051321],
positive regulation of filopodium assembly [GO:0051491],
positive regulation of synapse assembly [GO:0051965],
positive regulation of dendritic spine morphogenesis [GO:0061003],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of protein targeting to membrane [GO:0090314],
postsynaptic actin cytoskeleton organization [GO:0098974],
positive regulation of protein localization to plasma membrane [GO:1903078],
negative regulation of bleb assembly [GO:1904171],
positive regulation of actin cytoskeleton reorganization [GO:2000251],

Molecular Function:
structural constituent of cytoskeleton [GO:0005200],
protein binding [GO:0005515],
ATP binding [GO:0005524],
actin filament binding [GO:0051015],
nucleotide binding [GO:0000166],
actin binding [GO:0003779],
ATPase binding [GO:0051117],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
Arp2/3 protein complex [GO:0005885],
brush border [GO:0005903],
cell-cell junction [GO:0005911],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
lamellipodium [GO:0030027],
site of double-strand break [GO:0035861],
extracellular exosome [GO:0070062],
Golgi membrane [GO:0000139],
ruffle [GO:0001726],
podosome [GO:0002102],
cytoskeleton [GO:0005856],
actin filament [GO:0005884],
hemidesmosome [GO:0030056],
cell leading edge [GO:0031252],
cell projection [GO:0042995],
perinuclear region of cytoplasm [GO:0048471],
excitatory synapse [GO:0060076],
postsynapse [GO:0098794],
glutamatergic synapse [GO:0098978],