CALR

calreticulin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
24169561 ESC Human NO
25378661 Endometrial glandular cells derived from cervix Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479],
peptide antigen assembly with MHC class I protein complex [GO:0002502],
regulation of transcription, DNA-templated [GO:0006355],
protein folding [GO:0006457],
protein export from nucleus [GO:0006611],
cellular calcium ion homeostasis [GO:0006874],
receptor-mediated endocytosis [GO:0006898],
spermatogenesis [GO:0007283],
positive regulation of cell proliferation [GO:0008284],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of gene expression [GO:0010628],
negative regulation of translation [GO:0017148],
protein maturation by protein folding [GO:0022417],
cortical actin cytoskeleton organization [GO:0030866],
response to estradiol [GO:0032355],
negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144],
response to testosterone [GO:0033574],
protein localization to nucleus [GO:0034504],
protein folding in endoplasmic reticulum [GO:0034975],
ATF6-mediated unfolded protein response [GO:0036500],
regulation of meiotic nuclear division [GO:0040020],
response to drug [GO:0042493],
glucocorticoid receptor signaling pathway [GO:0042921],
regulation of apoptotic process [GO:0042981],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of cell cycle [GO:0045787],
negative regulation of transcription, DNA-templated [GO:0045892],
negative regulation of retinoic acid receptor signaling pathway [GO:0048387],
positive regulation of phagocytosis [GO:0050766],
protein stabilization [GO:0050821],
sequestering of calcium ion [GO:0051208],
cardiac muscle cell differentiation [GO:0055007],
negative regulation of cell cycle arrest [GO:0071157],
cellular response to lithium ion [GO:0071285],
cellular senescence [GO:0090398],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
negative regulation of trophoblast cell migration [GO:1901164],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane [GO:1990668],
positive regulation of dendritic cell chemotaxis [GO:2000510],

Molecular Function:
complement component C1q binding [GO:0001849],
DNA binding [GO:0003677],
RNA binding [GO:0003723],
mRNA binding [GO:0003729],
integrin binding [GO:0005178],
iron ion binding [GO:0005506],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
carbohydrate binding [GO:0030246],
ubiquitin protein ligase binding [GO:0031625],
peptide binding [GO:0042277],
hormone binding [GO:0042562],
protein binding involved in protein folding [GO:0044183],
androgen receptor binding [GO:0050681],
unfolded protein binding [GO:0051082],
chaperone binding [GO:0051087],
metal ion binding [GO:0046872],

Cellular Component:
acrosomal vesicle [GO:0001669],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
nuclear envelope [GO:0005635],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum lumen [GO:0005788],
smooth endoplasmic reticulum [GO:0005790],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
polysome [GO:0005844],
focal adhesion [GO:0005925],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
membrane [GO:0016020],
phagocytic vesicle membrane [GO:0030670],
sarcoplasmic reticulum lumen [GO:0033018],
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116],
MHC class I peptide loading complex [GO:0042824],
endoplasmic reticulum quality control compartment [GO:0044322],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556],
endocytic vesicle lumen [GO:0071682],
sarcoplasmic reticulum [GO:0016529],
macromolecular complex [GO:0032991],
intracellular membrane-bounded organelle [GO:0043231],