CALCRL

calcitonin receptor like receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
calcium ion transport [GO:0006816],
cell surface receptor signaling pathway [GO:0007166],
G-protein coupled receptor signaling pathway [GO:0007186],
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
heart development [GO:0007507],
protein transport [GO:0015031],
receptor internalization [GO:0031623],
negative regulation of smooth muscle contraction [GO:0045986],
positive regulation of smooth muscle cell proliferation [GO:0048661],
negative regulation of inflammatory response [GO:0050728],
cellular response to sucrose stimulus [GO:0071329],
calcitonin gene-related peptide receptor signaling pathway [GO:1990408],
adrenomedullin receptor signaling pathway [GO:1990410],
signal transduction [GO:0007165],
positive regulation of cell proliferation [GO:0008284],

Molecular Function:
adrenomedullin receptor activity [GO:0001605],
calcitonin gene-related peptide receptor activity [GO:0001635],
G-protein coupled receptor activity [GO:0004930],
calcitonin receptor activity [GO:0004948],
protein binding [GO:0005515],
protein transporter activity [GO:0008565],
adrenomedullin binding [GO:1990409],
transmembrane signaling receptor activity [GO:0004888],

Cellular Component:
cytoplasm [GO:0005737],
lysosome [GO:0005764],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
adrenomedullin receptor complex [GO:1903143],
CGRP receptor complex [GO:1990406],
membrane [GO:0016020],
integral component of membrane [GO:0016021],