CAD

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
liver development [GO:0001889],
'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207],
UTP biosynthetic process [GO:0006228],
glutamine metabolic process [GO:0006541],
nitrogen compound metabolic process [GO:0006807],
heart development [GO:0007507],
female pregnancy [GO:0007565],
lactation [GO:0007595],
response to amine [GO:0014075],
drug metabolic process [GO:0017144],
peptidyl-threonine phosphorylation [GO:0018107],
citrulline biosynthetic process [GO:0019240],
response to caffeine [GO:0031000],
animal organ regeneration [GO:0031100],
response to insulin [GO:0032868],
response to testosterone [GO:0033574],
cellular response to drug [GO:0035690],
response to starvation [GO:0042594],
'de novo' UMP biosynthetic process [GO:0044205],
pyrimidine nucleoside biosynthetic process [GO:0046134],
protein autophosphorylation [GO:0046777],
response to cortisol [GO:0051414],
cellular response to epidermal growth factor stimulus [GO:0071364],
pyrimidine nucleotide biosynthetic process [GO:0006221],
cellular amino acid metabolic process [GO:0006520],
metabolic process [GO:0008152],

Molecular Function:
aspartate carbamoyltransferase activity [GO:0004070],
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088],
dihydroorotase activity [GO:0004151],
protein kinase activity [GO:0004672],
ATP binding [GO:0005524],
zinc ion binding [GO:0008270],
enzyme binding [GO:0019899],
identical protein binding [GO:0042802],
aspartate binding [GO:0070335],
nucleotide binding [GO:0000166],
UTP binding [GO:0002134],
catalytic activity [GO:0003824],
amino acid binding [GO:0016597],
transferase activity [GO:0016740],
carboxyl- or carbamoyltransferase activity [GO:0016743],
hydrolase activity [GO:0016787],
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810],
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812],
ligase activity [GO:0016874],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
membrane [GO:0016020],
nuclear matrix [GO:0016363],
macromolecular complex [GO:0032991],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
terminal bouton [GO:0043195],
extracellular exosome [GO:0070062],